Mass Spectrometry Scientist

Yoh Idibu; Massachusetts; Presencial; USD 43.000 - 62.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Health benefits

401K Retirement plan

EAP

Direct deposit

Training opportunities

Descripción de la vacante

Yoh Life Sciences is seeking a Mass Spectrometry Scientist in Bristol, PA to act as a technical expert in LC-MS characterization and method development for ADCs and complex bioconjugates. The role spans process development and CMC activities, with emphasis on DAR, peptide mapping, PTMs, and data interpretation.

The position involves designing workflows for proteins, antibodies, and conjugates, supporting regulatory submissions, and collaborating with cross-functional teams and client sponsors.

Formación

• PhD in Analytical Chemistry, Chemistry, Biochemistry, Pharmaceutical Sciences, or related field; industry experience preferred or MS with 2+ years.
• Hands-on experience with LC-MS characterization of biologics, ADCs, or related conjugated therapeutics.
• Experience with high-resolution MS and interpretation of complex datasets.

Responsabilidades

• Lead development, optimization, and transfer of LC-MS methods for ADCs and related bioconjugates.
• Design and execute MS studies for intact proteins, antibodies, fragments, peptides, and conjugates.
• Perform DAR analysis, peptide mapping, PTM ID, conjugation site analysis, and stability assessment.
• Support process development, deviations, comparability, and product quality investigations.
• Develop robust sample prep workflows for LC-MS analyses of proteins, peptides, oligos.
• Interpret and communicate findings to cross-functional teams and sponsors.
• Support regulatory submissions including IND, BLA, and IMPD analytical sections.

Conocimientos

LC-MS characterization of biologics/AD

Data analysis software (Waters Connect

Educación

PhD in Analytical Chemistry or related

MS with 2+ years of relevant experience

Herramientas

Waters Connect

MassLynx

Descripción del empleo

Yoh Life Sciences is hiring for a Mass Spectrometry Scientist in Bristol, PA. This individual will serve as a technical expert in mass spectrometry-based characterization and method development across process development and CMC activities. The experienced LC-MS scientist will develop LC-MS methods for conjugate characterization activities supporting process development of antibody-drug conjugates (ADCs), oligonucleotide conjugates, radioconjugates, and other complex bioconjugate modalities.

Position: Mass Spec Scientist
Duration: contract to perm
Pay: $40-$45/DOE
Shift: M-F 8-5pm

Key Responsibilities

• Lead development, optimization, and transfer of LC-MS analytical methods supporting ADCs and related bioconjugate therapeutics.
• Design and execute mass spectrometry studies for characterization of intact proteins/antibodies, fragment antibodies, small format proteins, peptides, linker-payloads, oligonucleotides, and conjugated species.
• Perform characterization activities including DAR analysis, peptide mapping, PTM identification, conjugation site analysis, aggregation and fragmentation assessment, disulfide scrambling, free payload and linker impurity analysis, and stability studies.
• Support analytical investigations related to process development, manufacturing deviations, comparability, and product quality assessments.
• Develop robust sample preparation workflows for proteins, peptides, oligonucleotides, and conjugated modalities for LC-MS analyses.
• Interpret complex analytical datasets and communicate findings to cross-functional project teams and client sponsors.
• Support regulatory submissions including IND, BLA, and IMPD analytical sections.

Required Qualifications

• Ph.D. in Analytical Chemistry, Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with 0 years of industry experience; or M.S. with 2+ years of relevant experience.
• Experience with analytical characterization techniques including intact/reduced, subunit mass analysis, and peptide mapping.
• Extensive hands-on experience with LC-MS characterization of biologics, ADCs, or related conjugated therapeutics.
• Hands-on experience with high-resolution mass spectrometry techniques and interpretation of complex datasets.
• Strong understanding of protein chemistry, conjugation technologies, and biopharmaceutical analytical development.
• Experience with data analysis software such as Waters Connect, MassLynx, or equivalent platforms

Estimated Min Rate: $31.50

Estimated Max Rate: $45.00

What’s In It for You?

• Medical, Prescription, Dental & Vision Benefits (for employees working 20+ hours per week)
• Health Savings Account (HSA) (for employees working 20+ hours per week)
• Life & Disability Insurance (for employees working 20+ hours per week)
• MetLife Voluntary Benefits
• Employee Assistance Program (EAP)
• 401K Retirement Savings Plan
• Direct Deposit & weekly epayroll
• Referral Bonus Programs
• Certification and training opportunities

Note: Any pay ranges displayed are estimations. Actual pay is determined by an applicant's experience, technical expertise, and other qualifications as listed in the job description.

Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

For California applicants, qualified applicants with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. All of the material job duties described in this posting are job duties for which a criminal history may have a direct, adverse, and negative relationship potentially resulting in the withdrawal of a conditional offer of employment.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

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