Kilo & HPAPI Process Engineer - Greenfield Lab

BioSpace; Lebanon (IN); On-site; USD 66,000 - 172,000; Full time

Job summary

Lilly is seeking a Process Engineer for its Lebanon, Indiana site to support a pilot plant for API manufacturing, focusing on kilo-lab and high-potency operations. The role involves solving scale-up challenges, optimizing synthesis and isolation steps, and ensuring compliance with cgmp standards.

Initial location at Parkwood West, Indianapolis, with permanent site in Lebanon. Collaboration with chemists and engineers to advance manufacturing capabilities is essential.

Qualifications

• Deep technical interest in process development and chemical engineering.
• Ability to work in a cross-functional team and take accountability.
• Experience with kilo-scale equipment and scale-up factors (kinetics, mass transfer, heat transfer).
• Familiarity with HPAPI handling and containment practices (isolators, glove boxes).
• Working knowledge of crystallization, distillation, extraction, and unit operations.
• Understanding of cGMP requirements and ability to document technical work.

Responsibilities

• Evaluate scale-up feasibility and rig fit for new chemistries using data and modeling.
• Design, test and install new equipment to meet evolving portfolio needs.
• Operate and troubleshoot kilo-scale reactor systems and related equipment.
• Engineer containment and safe-handling strategies for HPAPI operations.
• Optimize unit operations across crystallization, distillation, extraction, and isolation.
• Ensure quality, safety, and cgmp compliance and document findings.
• Coordinate with HSE, QA, Tech Services, Development, Operations, Automation, and Manufacturing on projects.

Skills

Chemical engineering knowledge

Problem solving

Team collaboration

Strong communication

Education

BS/MS in chemical engineering

Tools

DeltaV

Dynochem

Aspen

Electronic lab notebooks

Job description

Lilly is seeking a Process Engineer for its Lebanon, Indiana site to support a pilot plant for API manufacturing, focusing on kilo-lab and high-potency operations. The role involves solving scale-up challenges, optimizing synthesis and isolation steps, and ensuring compliance with cgmp standards.

Initial location at Parkwood West, Indianapolis, with permanent site in Lebanon. Collaboration with chemists and engineers to advance manufacturing capabilities is essential.