Kilo Lab & HPAPI Process Engineer

Eli Lilly and Company; Indianapolis (IN); Presencial; USD 66 000 - 172 000; Tempo integral

Vantagens oferecidas por esta oferta de emprego

Company bonus

401(k) plan

Vacation benefits

Health insurance

Resumo da oferta

Eli Lilly and Company in Indianapolis, IN is seeking a Process Engineer to support the pilot plant for API production in the Kilo Lab and High Potency Lab. You will help scale up gram to kilogram reactions, design and install new equipment, and ensure containment and cGMP compliance.

The role emphasizes cross-functional collaboration with chemists and operations, development of process knowledge, and optimization of crystallization, distillation, and isolation steps to enable GMP manufacturing

Qualificações

• BS or MS in chemical engineering and 1–4 years in pharma API manufacturing or development.
• Authorized to work in the United States full-time; Lilly will not sponsor visas or work authorization for this role.

Responsabilidades

• Evaluate scale-up feasibility for new chemistries by analyzing technical data packages and running kinetic, mass-transfer, and heat-transfer modeling and experiments to ensure clean transfer from gram- to kilogram-scale reactors.
• Design, test and install new equipment to meet evolving portfolio and reaction needs.
• Design, operate, and troubleshoot kilo-scale reactor systems — glass-lined and Hastelloy reactors, agitated filter-dryers — with Kilo Lab and High Potency Lab chemists and plant design.
• Engineer containment and safe-handling strategies for HPAPI operations, including isolators and glove boxes, OEB, and dry-end solids processing.
• Optimize crystallization, distillation, extraction, and isolation steps, resolve polymorphism and particle-size challenges while closing mass balances and tracking impurity fate.
• Safeguard quality, safety, and cGMP compliance; author or review technical reports, regulatory submissions, and lab notebooks to a high standard.
• Coordinate with HSE, QA, Tech Services, Development, Operations, Automation, and Manufacturing; develop project plans and timetables with a proactive quality mindset.
• Develop or review plans and timetables for project work.

Conhecimentos

Process engineering

Kilo Lab

HPAPI containment

Scale-up

cGMP compliance

Kinetic modeling

Cross-functional teamwork

Documentation

Formação académica

Chemical engineering degree

Ferramentas

DeltaV

Dynochem

Aspen

ELN

Descrição da oferta de emprego

Eli Lilly and Company in Indianapolis, IN is seeking a Process Engineer to support the pilot plant for API production in the Kilo Lab and High Potency Lab. You will help scale up gram to kilogram reactions, design and install new equipment, and ensure containment and cGMP compliance.

The role emphasizes cross-functional collaboration with chemists and operations, development of process knowledge, and optimization of crystallization, distillation, and isolation steps to enable GMP manufacturing