Genome Editing Scientist — In Vitro Assays & Translational

stylusmedicine; Cambridge (MA); On-site; USD 125,000 - 140,000; Full time

Job summary

Stylus Medicine is seeking a Scientist to join the Genome Sciences & Engineering team to advance in vitro functional assessment of lead genome editors for translational and preclinical programs. The role focuses on assay development, data analysis, and cross-functional collaboration to accelerate next-generation gene editing therapies.

You will work with primary human cells (T cells, hepatocytes), LNP delivery, and multiple sequencing and QC approaches, contributing to discovery and platform

Qualifications

• PhD in Cell Biology, Molecular Biology, or related field; or MS with 5+ years or BS with 7+ years of relevant experience.
• Hands-on experience with LNP delivery and culturing primary cells (including, but not limited to T-cells and hepatocytes) and/or cancer cell lines.
• Working knowledge of gene editing technologies (CRISPR nucleases, recombinases, base editors, or transcriptional effectors).
• Experience with flow cytometry and laboratory automation platforms for cell-based screening workflows.
• Proficiency in nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR.
• Track record of independently generating reproducible data and performing rigorous quantitative analysis.
• Strong written and verbal communication skills, with the ability to present complex technical information to both specialist and non-specialist audiences.
• Exceptional organizational skills, comfortable managing complex datasets and overlapping projects.
• Strategic thinker who plans and prioritizes for scientific impact.
• Clear, approachable communicator who makes complex concepts accessible across disciplines.
• Collaborative mindset with a team-first attitude.
• Decisive problem-solver who thrives amid scientific uncertainty.

Responsibilities

• Design and execute in vitro functional assays that support candidate selection and preclinical development of lead genome editors, advancing platform and program objectives.
• Develop and optimize molecular (ddPCR, qPCR) and cytogenetic (KromaTiD, optical genome mapping) assays to measure genome editor activity, specificity, transgene copy number, TCR repertoire, and biodistribution.
• Support genome editor engineering campaigns by running high-throughput screens in relevant cell lines, including primary human T-cells, and delivering timely, decision-quality data to guide candidate selection.
• Troubleshoot experiments, analyze data, and translate results into actionable scientific insights.
• Maintain detailed laboratory notebooks and clearly communicate data and findings to the broader scientific team.
• Partner across R&D to advance optimized candidates into translational and preclinical development.

Skills

LNP delivery

Primary cell culture

T-cells culture

Cancer cell lines

CRISPR

Recombinases

Base editors

Transcriptional effectors

Flow cytometry

Laboratory automation

TapeStation

Qubit

NanoDrop

qPCR

Data analysis

Communication

Organization

Strategic thinking

Interdisciplinary communication

Collaboration

Problem-solving

Education

PhD in Cell Biology / Molecular Biology

MS with 5+ years of experience

BS with 7+ years of experience

Job description

Stylus Medicine is seeking a Scientist to join the Genome Sciences & Engineering team to advance in vitro functional assessment of lead genome editors for translational and preclinical programs. The role focuses on assay development, data analysis, and cross-functional collaboration to accelerate next-generation gene editing therapies.

You will work with primary human cells (T cells, hepatocytes), LNP delivery, and multiple sequencing and QC approaches, contributing to discovery and platform