Scientist, Genome Sciences & Engineering

stylusmedicine; Cambridge (MA); On-site; USD 125,000 - 140,000; Full time

Job summary

Stylus Medicine is seeking a Scientist to join the Genome Sciences & Engineering team to advance in vitro functional assessment of lead genome editors for translational and preclinical programs. The role focuses on assay development, data analysis, and cross-functional collaboration to accelerate next-generation gene editing therapies.

You will work with primary human cells (T cells, hepatocytes), LNP delivery, and multiple sequencing and QC approaches, contributing to discovery and platform

Qualifications

• PhD in Cell Biology, Molecular Biology, or related field; or MS with 5+ years or BS with 7+ years of relevant experience.
• Hands-on experience with LNP delivery and culturing primary cells (including, but not limited to T-cells and hepatocytes) and/or cancer cell lines.
• Working knowledge of gene editing technologies (CRISPR nucleases, recombinases, base editors, or transcriptional effectors).
• Experience with flow cytometry and laboratory automation platforms for cell-based screening workflows.
• Proficiency in nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR.
• Track record of independently generating reproducible data and performing rigorous quantitative analysis.
• Strong written and verbal communication skills, with the ability to present complex technical information to both specialist and non-specialist audiences.
• Exceptional organizational skills, comfortable managing complex datasets and overlapping projects.
• Strategic thinker who plans and prioritizes for scientific impact.
• Clear, approachable communicator who makes complex concepts accessible across disciplines.
• Collaborative mindset with a team-first attitude.
• Decisive problem-solver who thrives amid scientific uncertainty.

Responsibilities

• Design and execute in vitro functional assays that support candidate selection and preclinical development of lead genome editors, advancing platform and program objectives.
• Develop and optimize molecular (ddPCR, qPCR) and cytogenetic (KromaTiD, optical genome mapping) assays to measure genome editor activity, specificity, transgene copy number, TCR repertoire, and biodistribution.
• Support genome editor engineering campaigns by running high-throughput screens in relevant cell lines, including primary human T-cells, and delivering timely, decision-quality data to guide candidate selection.
• Troubleshoot experiments, analyze data, and translate results into actionable scientific insights.
• Maintain detailed laboratory notebooks and clearly communicate data and findings to the broader scientific team.
• Partner across R&D to advance optimized candidates into translational and preclinical development.

Skills

LNP delivery

Primary cell culture

T-cells culture

Cancer cell lines

CRISPR

Recombinases

Base editors

Transcriptional effectors

Flow cytometry

Laboratory automation

TapeStation

Qubit

NanoDrop

qPCR

Data analysis

Communication

Organization

Strategic thinking

Interdisciplinary communication

Collaboration

Problem-solving

Education

PhD in Cell Biology / Molecular Biology

MS with 5+ years of experience

BS with 7+ years of experience

Job description

About Stylus Medicine:

Stylus Medicine is developing transformative in vivo genetic medicines to unlock cures. Stylus combines engineered recombinases with non-viral delivery to specifically encode therapeutics. The company's approach is versatile and modular, with potential therapeutic application across oncology, autoimmune, genetic diseases, and beyond.

About the Role:

Stylus Medicine is seeking a Scientist to join our Genome Sciences & Engineering team to drive innovation in next-generation gene editing therapies. In this role, the Scientist will drive the in vitro functional assessment of the company's lead genome editors to support the advancement of the company's lead programs through translational and preclinical development. This individual will play a key role in discovery and engineering efforts, advancing LSR-based genome editing platforms and collaborating across diverse R&D teams.

Key Responsibilities & Accountabilities:

• Design and execute in vitro functional assays that support candidate selection and preclinical development of lead genome editors,advancing platform and program objectives
• Develop and optimize molecular (ddPCR, qPCR) and cytogenetic (KromaTiD, optical genome mapping) assays to measure genome editor activity, specificity, transgene copy number, TCR repertoire, and biodistribution
• Support genome editor engineering campaigns by running high-throughput screens in relevant cell lines, including primary human T-cells, and delivering timely, decision-quality data to guide candidate selection
• Troubleshoot experiments, analyze data, and translate results into actionable scientific insights
• Maintain detailed laboratory notebooks and clearly communicate data and findings to the broader scientific team
• Partner across R&D to advance optimized candidates into translational and preclinical development

Qualifications & Skills:

• PhD in Cell Biology, Molecular Biology, or a related field; or MS with 5+ years or BS with 7+ years of relevant experience
• Hands-on experience with LNP delivery and expertise culturing primary cells (including, but not limited to T-cells and hepatocytes) and/or cancer cell lines
• Working knowledge of gene editing technologies (CRISPR nucleases, recombinases, base editors, or transcriptional effectors)
• Experience with flow cytometry and laboratory automation platforms for cell-based screening workflows
• Proficiency in nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR
• Track record of independently generating reproducible data and performing rigorous quantitative analysis
• Strong written and verbal communication skills, with the ability to present complex technical information to both specialist and non-specialist audiences
• Exceptional organizational skills, comfortable managing complex datasets and overlapping projects
• Strategic thinker who plans and prioritizes for scientific impact
• Clear, approachable communicator who makes complex concepts accessible across disciplines
• Collaborative mindset with a team-first attitude
• Decisive problem-solver who thrives amid scientific uncertainty

Pay Range: $125,000 - $140,000