Lead Scientist: In Vivo Genome Editing for Pediatrics

St. Jude Children's Research Hospital, Inc.; Memphis (TN); On-site; USD 126,000 - 238,000; Full time

Benefits offered by this job

Relocation assistance

Professional development

Competitive benefits

Job summary

St. Jude Children’s Research Hospital invites a Lead or Senior Scientist to spearhead the development of an in vivo base editing platform for patient‑specific treatments.

The role emphasizes team leadership, translational genome editing, and advancing drug products toward IND‑enabling studies and clinical trials. The Tsai Lab seeks an experienced scientist with a strong publishing record, capable of coordinating cross‑functional efforts, and driving program milestones in a highly collaborative

Qualifications

• PhD in relevant scientific area (genomics, molecular and cell biology)
• Expertise in genome editing, genomics, and next‑generation sequencing
• Excellent communication, organizational, and presentation skills
• Four+ years hands‑on lab experience with CRISPR genome editors and NGS library prep

Responsibilities

• Design and develop in vivo base editing drug products for bone marrow failure disorders
• Characterize genotoxicity of candidate products using state‑of‑the‑art genomic assays
• Optimize potency and specificity of an HSC‑targeted delivery approach
• Co‑lead a multi‑disciplinary team to test a streamlined in vivo genome editing platform
• Coordinate a team to develop a novel gene editing platform
• Accelerate lead‑target discovery, genotoxicity characterization, and cargo optimization
• Conduct non‑clinical pharmacology studies of HSC‑targeted lipid nanoparticles
• Assess and manage project risks and analyze outcomes
• Summarize results and present updates to DRIVE and ARPA‑H teams
• Draft manuscripts for publication in high‑impact journals

Skills

Genome editing

Genomics

NGS library prep

Education

PhD in genomics/molecular and cell biology

Tools

NGS

CHANGE-seq

Job description

St. Jude Children’s Research Hospital invites a Lead or Senior Scientist to spearhead the development of an in vivo base editing platform for patient‑specific treatments.

The role emphasizes team leadership, translational genome editing, and advancing drug products toward IND‑enabling studies and clinical trials. The Tsai Lab seeks an experienced scientist with a strong publishing record, capable of coordinating cross‑functional efforts, and driving program milestones in a highly collaborative