Genome Editing Scientist — Build Therapeutic Cell Models

Stealth Biotech; New York (NY); On-site; USD 130,000 - 190,000; Full time

Job summary

Stealth Biotech, an early-stage startup in New York, seeks a Scientist - Genome Engineer to design, build, and validate genome editing approaches in human cellular disease models. You will own editing work from design to readout, shaping the platform, lab, and scientific culture, in close collaboration with the founding team.

You will lead multiple editing strategies, compare delivery methods across viral and non-viral systems, and drive IND-enabling experiments while mentoring team members and

Qualifications

• PhD in genetics, molecular biology, bioengineering or closely related field.
• Hands-on genome editing with CRISPR-Cas, base editors, prime editors.
• Experience with multiple delivery systems.
• Editing primary cells or therapeutically relevant cells with quantitative readouts (NGS, PCR, flow).
• Strong experimental design, data analysis and sequencing data handling.
• Ability to work independently in a small team and communicate clearly.

Responsibilities

• Design and execute precision editing strategies.
• Build and screen libraries; optimize editing efficiency in cells.
• Develop and compare delivery approaches for viral and non-viral systems.
• Run specificity and safety assays; analyze off-targets and large deletions.
• Own experimental design, data analysis and documentation for IND-enabling work.
• Manage team members, equipment, protocols, vendor relationships.

Skills

CRISPR design

Base editing

Prime editing

Delivery systems

NGS analysis

Flow cytometry

Experimental design

Scientific communication

Education

PhD in genetics / molecular biology / bioengineering

Tools

CRISPR design tools

Bioinformatics pipelines

Job description

Stealth Biotech, an early-stage startup in New York, seeks a Scientist - Genome Engineer to design, build, and validate genome editing approaches in human cellular disease models. You will own editing work from design to readout, shaping the platform, lab, and scientific culture, in close collaboration with the founding team.

You will lead multiple editing strategies, compare delivery methods across viral and non-viral systems, and drive IND-enabling experiments while mentoring team members and