Lead Scientist - In Vivo Genome Editing for Personalized Therapies

St Jude Children's Research Hospital; Memphis (TN); On-site; USD 126,000 - 238,000; Full time

Job summary

St. Jude Children's Research Hospital seeks a Lead Scientist to guide the development of an in vivo base editing platform for pediatric patients with bone marrow disorders.

You will lead efforts in genome editing drug development, IND-enabling studies, and translation to clinical trials with room for growth. The role requires a PhD with extensive experience in genomics and CRISPR, and a track record of managing multidisciplinary teams in a fast-paced research lab environment.

Qualifications

• PhD in relevant scientific area is required, such as genomics, molecular and cell biology.
• Expertise in genome editing, genomics, next-generation sequencing.
• Excellent communication, organizational, and presentation skills.
• Four or more years of hands-on research laboratory experience working with CRISPR genome editors and NGS library preparation.

Responsibilities

• Coordinate a team of scientists to develop a novel gene editing platform.
• Accelerate lead-target discovery, genotoxicity characterization, and cargo optimization.
• Conduct non-clinical pharmacology studies of an HSC-targeted lipid nanoparticle.
• Continuously assess and manage project technical and drug development risks.
• Analyze experimental outcomes and develop high-quality summaries.
• Summarize results and present updates to DRIVE and ARPA-H teams.
• Draft manuscripts and figures for publication in high-impact journals.

Skills

Genomics

Genome editing

NGS library prep

CRISPR editors

Data interpretation

Team leadership

Education

PhD in genomics/molecular/cell biology

Master’s degree in relevant field

Bachelor’s degree in related field

Job description

St. Jude Children's Research Hospital seeks a Lead Scientist to guide the development of an in vivo base editing platform for pediatric patients with bone marrow disorders.

You will lead efforts in genome editing drug development, IND-enabling studies, and translation to clinical trials with room for growth. The role requires a PhD with extensive experience in genomics and CRISPR, and a track record of managing multidisciplinary teams in a fast-paced research lab environment.