Lead Scientist, In Vivo Genome Editing & Therapies

St. Jude Children's Research Hospital; Memphis (TN); On-site; USD 104,000 - 238,000; Full time

Job summary

St. Jude Children’s Research Hospital in Memphis invites applications for Lead or Senior Scientist in the Tsai Lab to advance an in vivo base editing platform for bone marrow disorders.

The role focuses on developing personalized genome editing therapies, performing IND-enabling studies, and preparing drug products for clinical trials with substantial room for career growth. Collaborate with cross-disciplinary teams within DRIVE and ARPA-H partnerships to translate genome editing into patient

Qualifications

• Proven expertise in genome editing drug development.
• Experience leading multi-disciplinary teams.
• Strong record of publications and collaboration.

Responsibilities

• Design and develop in vivo base editing drug products for bone marrow disorders.
• Characterize genotoxicity using state-of-the-art genomic assays.
• Optimize potency and specificity of HSC-targeted delivery approaches.
• Co-lead a multi-disciplinary team to test platform approaches for in vivo genome editing medicines.
• Coordinate a team of scientists to advance a novel gene editing platform.

Skills

Genome editing

Drug development

Leadership

IND-enabling studies

Education

PhD in a relevant field

Postdoc or equivalent

Tools

CHANGE-seq-BE

CHANCE-seq

LNP delivery

Job description

St. Jude Children’s Research Hospital in Memphis invites applications for Lead or Senior Scientist in the Tsai Lab to advance an in vivo base editing platform for bone marrow disorders.

The role focuses on developing personalized genome editing therapies, performing IND-enabling studies, and preparing drug products for clinical trials with substantial room for career growth. Collaborate with cross-disciplinary teams within DRIVE and ARPA-H partnerships to translate genome editing into patient