Discovery Scientist: Gene Editing & Protein Engineering

Basecamp Research; Boston (MA); On-site; USD 110,000 - 140,000; Full time

Job summary

Basecamp Research, based in Cambridge, MA, seeks a Scientist I to leverage biodiversity knowledge for gene editing and cellular engineering solutions. You will work with Data Science/AI teams to tackle challenging problems and contribute to the development of transformative therapeutics.

You will perform high-throughput assays, develop new methods, and collaborate across biology, engineering, and production to deliver scalable, regulatory-ready workflows.

Qualifications

• PhD in molecular biology, biochemistry, genetics, bioengineering, or life-sciences related field, or MSc with equivalent hands-on lab experience.
• Experience with gene editing, NGS assay development, protein engineering and cell therapy.
• Experience with high-throughput methods of cloning and producing DNA constructs for cellular screening.
• Experience with mammalian cell culture, transfection, and cell-line generation.
• Knowledge of emerging technologies in gene editing and on/off-target analytics that enable regulatory approval.
• Expertise with DNA/RNA extraction, PCR, ddPCR, NGS library preparation and QC.
• Excellent communication skills to both internal and external stakeholders.

Responsibilities

• Contribute to strategy for design, build, test cycles of novel protein enzymes, with discovery, validation, and engineering of novel gene editing tools.
• Build and screen plasmid libraries, and develop cloning workflows at scale.
• Quantify editing outcomes using ddPCR, qPCR, flow-cytometry and NGS readouts.
• Optimise hits for activity and specificity using human primary cells and cell lines for lead development.
• Establish strong documentation practices and lab SOPs as a founding member of the lab team.

Skills

Gene editing

NGS assay development

Protein engineering

High-throughput cloning

Mammalian cell culture

Transfection

Cell-line generation

DNA/RNA extraction

PCR

ddPCR

NGS library prep

Communication skills

Education

PhD in molecular biology / related field

Tools

Flow cytometry

NGS instrumentation

Job description

Basecamp Research, based in Cambridge, MA, seeks a Scientist I to leverage biodiversity knowledge for gene editing and cellular engineering solutions. You will work with Data Science/AI teams to tackle challenging problems and contribute to the development of transformative therapeutics.

You will perform high-throughput assays, develop new methods, and collaborate across biology, engineering, and production to deliver scalable, regulatory-ready workflows.