Genome Engineering Co-op: Gene Editing & Transgenic Models

Regeneron Pharmaceuticals; Tarrytown (GA); On-site; USD 25,000 - 70,000; Full time

Job summary

Regeneron Pharmaceuticals, in Tarrytown, NY, invites applications for a 2027 Co-op in Genome Engineering & Transgenic Model Development to advance VelociGene activities. The role focuses on validating gene-editing tools in cells and mouse models, with hands-on DNA techniques and protein analyses.

You will collaborate with scientists to optimize an editing platform, screen variants, and apply structure-prediction methods, while maintaining rigorous documentation and safety standards.

Qualifications

• Must be enrolled in, or accepted to, an academic program pursuing an Undergraduate or Graduate degree.
• Must be able to commit to 40 hours per week from January-August, May/June-December, or August-December.
• GPA of 3.0 or higher preferred.
• Demonstrated leadership in activities, clubs, sports, work, or community preferred.

Responsibilities

• Contribute to the development of a proprietary gene-editing enhancement platform designed for both in vitro and in vivo use.
• Screen engineered protein variants using a fluorescence-based reporter assay to identify compact, enhanced versions that retain function.
• Apply computational structure-prediction tools to help design engineered protein variants.
• Evaluate a modified, DNA-nicking version of Cas9 to assess whether it reduces unwanted genomic effects while preserving editing efficiency.
• Perform basic molecular biology techniques such as PCR, cloning and subcloning, and western blotting.
• Perform mammalian cell culture techniques, including sterile technique, passaging, and transfection or electroporation.
• Work with viral vectors and flow cytometry methods.
• Document experimental procedures and results using tools such as Excel and Prism, and collaborate with scientists across the VelociGene team.

Skills

Molecular biology

PCR

Cloning

Cell culture

Flow cytometry

Western blotting

Fluorescence-based reporter assay

Computational structure prediction

Collaboration

Education

Undergraduate or Graduate degree pursuit

Returning to school after position

Tools

Excel

Prism

Job description

Regeneron Pharmaceuticals, in Tarrytown, NY, invites applications for a 2027 Co-op in Genome Engineering & Transgenic Model Development to advance VelociGene activities. The role focuses on validating gene-editing tools in cells and mouse models, with hands-on DNA techniques and protein analyses.

You will collaborate with scientists to optimize an editing platform, screen variants, and apply structure-prediction methods, while maintaining rigorous documentation and safety standards.