Senior Scientist, Protein Characterisation (Biologics)

IMMUNOCORE LTD; Duns Tew; On-site; GBP 55,000 - 75,000; Full time

Job summary

Immunocore is seeking a Senior Scientist I to advance characterisation of biopharmaceuticals. The role focuses on peptide mapping (LC-MS/MS), intact mass analysis, and glycosylation profiling in a biopharma environment.

You will work across microbial and mammalian expression systems, guide method development, and contribute to process development and study reporting while mentoring colleagues in a collaborative setting.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Characterisation of proteins expressed in microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Bench-based biopharmaceutical laboratory experience.
• Expert in electrophoretic, chromatographic and mass spectrometry techniques.
• Experience in assay development.

Responsibilities

• Supporting drug substance and drug product impurity characterisation and identification.
• Performing protein sequence and post translational modification identification, including glycosylation analysis.
• Supporting drug substance and drug product process development by performing characterisation of process intermediates.
• Contribute to the development of characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis.
• Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Independently testing and, increasingly, leading lines of investigation and proposing new experiments.

Skills

Protein analysis

Mass spectrometry

Glycosylation analysis

Assay development

Team mentoring

Education

BSc or MSc in biochemistry/biotechnology

PhD (desirable)

Tools

HPLC

Mass spectrometry instruments

Job description

Immunocore is seeking a Senior Scientist I to advance characterisation of biopharmaceuticals. The role focuses on peptide mapping (LC-MS/MS), intact mass analysis, and glycosylation profiling in a biopharma environment.

You will work across microbial and mammalian expression systems, guide method development, and contribute to process development and study reporting while mentoring colleagues in a collaborative setting.