Senior Scientist I: Protein Characterisation & MS

IMMUNOCORE LTD; Marston Meysey; On-site; GBP 55,000 - 75,000; Full time

Job summary

Oxford Immunocore in the UK is seeking a Senior Scientist I - Characterisation to drive biochemical characterisation and mass spectrometry studies for biopharmaceutical products. You will contribute to method development, stability studies and comparative analyses, and you will assist in writing protocols and reports while mentoring peers.

Focused on delivering first-in-class biological therapies, you will work in a collaborative team applying LC-MS/MS, HPLC peptide mapping and glycosylation

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency.
• Presented detailed scientific findings and papers to internal and external audiences.

Responsibilities

• Supporting drug substance and drug product impurity characterisation and identification.
• Performing protein sequence and post translational modification identification, including glycosylation analysis.
• Supporting drug substance and drug product process development by performing characterisation of process intermediates.
• Contribute to the Development of characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis.
• Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information.
• Priorities: establishing priorities for own work and team-based projects; making decisions on prioritisation based on the overall goals of the team.
• Technical Knowledge: sharing knowledge with the wider team and across departments; mentoring where appropriate.
• Laboratory records: ensuring that all records and information are up to date and recorded to the correct standard.
• Laboratory equipment: providing technical guidance to others on equipment usage.
• Reporting: communicating and presenting research findings at meetings with colleagues, senior management and partners.
• Adhere to safe working practices in laboratories according to EHS policies.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterisation

Assay development

Biopharmaceutical stability studies

Team collaboration

Scientific reporting

Technique assessment

Education

BSc or MSc in biochemistry/biotechnology or related

PhD in related discipline

Tools

LC-MS/MS

HPLC

Mass spectrometry

Job description

Oxford Immunocore in the UK is seeking a Senior Scientist I - Characterisation to drive biochemical characterisation and mass spectrometry studies for biopharmaceutical products. You will contribute to method development, stability studies and comparative analyses, and you will assist in writing protocols and reports while mentoring peers.

Focused on delivering first-in-class biological therapies, you will work in a collaborative team applying LC-MS/MS, HPLC peptide mapping and glycosylation