Senior Scientist I, Biologics Characterisation (MS)

IMMUNOCORE LTD; Stoke Hammond; Presencial; GBP 65 000 - 90 000; Tempo integral

Resumo da oferta

Immunocore Ltd in Oxford is seeking a Senior Scientist I - Characterisation to lead and execute protein characterisation studies for biopharmaceutical products. You will apply HPLC peptide mapping, LC-MS/MS and glycosylation analysis to recombinant proteins and antibodies, and contribute to method development and stability assessments.

You will collaborate across disciplines, document results, mentor colleagues, and ensure data integrity in a GMP-like environment, driving efficiency and

Qualificações

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry areas.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles.
• Worked in diverse team environments and driven improvements in working practices.
• Presented detailed scientific findings to internal and external audiences.

Responsabilidades

• Supporting drug substance and drug product impurity characterisation and identification.
• Performing protein sequence and post translational modification identification, including glycosylation analysis.
• Supporting drug substance and drug product process development by characterisation of process intermediates.
• Contribute to the development of characterisation methods of ImmTAX and other products, including peptide mapping and intact mass analysis.
• Designing and carrying out biochemical characterisation, chemical stability and comparability studies.
• Contribute to writing study protocols and reports.
• Independently testing and leading lines of investigation; proposing new experiments based on data and information.
• Priorities: establishing priorities for own work and team projects; making decisions based on evidence.
• Technical knowledge sharing across departments; mentoring and advancing new techniques.
• Laboratory records: ensuring up-to-date records; encouraging others to achieve this.
• Laboratory equipment: providing guidance on equipment use.
• Reporting: communicating research findings at meetings with colleagues, senior management and partners.
• Adhere to safe working practices in laboratories per EHS policies.

Conhecimentos

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterisation

Mammalian expression

Microbial expression

Post-translational mods

Assay development

Stability studies

Team collaboration

Data presentation

Method development

Project leadership

Formação académica

BSc or MSc in biochemistry/related

PhD (Desirable)

Ferramentas

LC-MS/MS

HPLC

Descrição da oferta de emprego

Immunocore Ltd in Oxford is seeking a Senior Scientist I - Characterisation to lead and execute protein characterisation studies for biopharmaceutical products. You will apply HPLC peptide mapping, LC-MS/MS and glycosylation analysis to recombinant proteins and antibodies, and contribute to method development and stability assessments.

You will collaborate across disciplines, document results, mentor colleagues, and ensure data integrity in a GMP-like environment, driving efficiency and