Senior Scientist I: Biologics Characterisation & MS

IMMUNOCORE LTD; Berrick Salome; Presencial; GBP 55.000 - 75.000; Jornada completa

Descripción de la vacante

Oxford Immunocore is seeking a Senior Scientist I in Characterisation (CMC) to drive protein characterisation using LC-MS/MS peptide mapping and mass spectrometry. You will contribute to method development for ImmTAX biologics and support biochemical stability studies, with emphasis on accurate record-keeping and safety.

Applicants should have a BSc/MSc (or PhD preferred) in biochemistry or related field and substantial bench experience in recombinant protein analysis, with a track record of

Formación

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic/chromatographic/mass spectrometry areas.
• Experienced in assay development
• Familiar with biopharmaceutical stability study principles and interpretation thereof
• Worked and contributed actively in a diverse team environment
• Proposed and driven changes in working practices that have improved efficiency
• Presented detailed scientific findings and papers to internal and external audiences

Responsabilidades

• Characterisation of drug substance and drug product impu- rity profiles (biologics).
• Develop and apply peptide mapping (LC-MS/MS) methods.
• Perform mass spectrometry based characterisation of proteins/antibodies.
• Contribute to method development for ImmTAX products.
• Design and perform biochemical characterisation, chemical stability and comparability studies.
• Prepare study protocols and reports; present findings to teams.
• Provide technical guidance and mentorship when needed.
• Ensure laboratory records are accurate and up to date.
• Adhere to EHS policies and safe working practices.

Conocimientos

HPLC peptide mapping

Mass spectrometry characterisation

Glycosylation analysis

Protein characterisation

Assay development

Bench biopharmaceutical experience

Team collaboration

Communication of scientific data

Educación

BSc or MSc in biochemistry/biotechnology or related

PhD in related discipline

Herramientas

LC-MS/MS

HPLC

Descripción del empleo

Oxford Immunocore is seeking a Senior Scientist I in Characterisation (CMC) to drive protein characterisation using LC-MS/MS peptide mapping and mass spectrometry. You will contribute to method development for ImmTAX biologics and support biochemical stability studies, with emphasis on accurate record-keeping and safety.

Applicants should have a BSc/MSc (or PhD preferred) in biochemistry or related field and substantial bench experience in recombinant protein analysis, with a track record of