Senior Scientist - Biologics Characterisation & MS

IMMUNOCORE LTD; West Ilsley; On-site; GBP 65,000 - 90,000; Full time

Job summary

Immunocore Ltd in the UK is seeking a Senior Scientist I - Characterisation within the CMC team in Oxford. You will develop and apply analytical methods to characterise biopharmaceutical proteins, focusing on peptide mapping, mass spectrometry, glycosylation analyses and stability studies.

You will design experiments, interpret data, and contribute to reports and protocols. A strong bench-based background in biopharma with GMP-related awareness is essential for this role.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic, or mass spectrometry methods.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices to improve efficiency.
• Presented detailed scientific findings and papers to internal and external audiences.

Responsibilities

• Supporting drug substance and drug product impurity characterisation and identification.
• Performing protein sequence and post translational modification identification, including glycosylation analysis.
• Supporting drug substance and drug product process development by characterisation of process intermediates.
• Contribute to the development of characterisation methods for ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis.
• Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Independently testing and leading lines of investigation; proposing new experiments based on data.
• Prioritising own work and team projects using evidence and experience.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterisation

Assay development

Biopharma lab experience

Data interpretation

Education

BSc/MSc in biochemistry/biotechnology or related

PhD in related discipline

Tools

LC-MS/MS

Chromatography

Job description

Immunocore Ltd in the UK is seeking a Senior Scientist I - Characterisation within the CMC team in Oxford. You will develop and apply analytical methods to characterise biopharmaceutical proteins, focusing on peptide mapping, mass spectrometry, glycosylation analyses and stability studies.

You will design experiments, interpret data, and contribute to reports and protocols. A strong bench-based background in biopharma with GMP-related awareness is essential for this role.