Senior Scientist I - Biopharma Protein Characterisation

IMMUNOCORE LTD; Chieveley; On-site; GBP 70,000 - 95,000; Full time

Job summary

Immunocore is recruiting a Senior Scientist I - Characterisation (CMC) in the UK. The role focuses on characterising biologics and biopharmaceutical products using peptide mapping (LC-MS/MS), intact mass analysis and HS-MS/MS techniques.

You will coordinate extensive testing of protein biomolecules, contribute to development of assays, stability studies and data-driven process improvements within a collaborative, cross-functional team.

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry areas.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency and supported teams.

Responsibilities

• Supporting drug substance and drug product impurity characterisation and identification.
• Performing protein sequence and post translational modification identification, including glycosylation analysis.
• Supporting drug substance and drug product process development by characterisation of process intermediates.
• Contribute to the development of characterisation methods for ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis.
• Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Independently testing and leading lines of investigation, proposing new experiments.
• Prioritising work and making decisions based on goals and evidence.
• Sharing knowledge across teams and mentoring colleagues.
• Maintaining laboratory records and ensuring proper use of equipment.
• Presenting findings to colleagues, senior management and partners.
• Adhere to safe working practices in laboratories.

Skills

Peptide mapping

Mass spectrometry

Glycosylation analysis

Protein biochemistry

Education

BSc or MSc in biochemistry/biotechnology or related

PhD in related discipline

Tools

HPLC peptide mapping

Mass spectrometry instrumentation

Job description

Immunocore is recruiting a Senior Scientist I - Characterisation (CMC) in the UK. The role focuses on characterising biologics and biopharmaceutical products using peptide mapping (LC-MS/MS), intact mass analysis and HS-MS/MS techniques.

You will coordinate extensive testing of protein biomolecules, contribute to development of assays, stability studies and data-driven process improvements within a collaborative, cross-functional team.