Biopharma Characterisation Scientist I

IMMUNOCORE LTD; Great Hampden; On-site; GBP 65,000 - 90,000; Full time

Job summary

IMMUNOCORE LTD in the UK is seeking a Senior Scientist I - Characterisation to advance protein characterisation for biologics and TCR-based products. You will conduct HPLC peptide mapping and mass spectrometry-based analyses, validate PTMs, and lead characterisation campaigns for recombinant proteins across microbial and mammalian systems.

The role emphasizes independent testing, data interpretation, and collaboration with multidisciplinary teams to drive assay development and GMP-aligned work

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency.
• Presented detailed scientific findings and papers to internal and external audiences.

Responsibilities

• Supporting drug substance and drug product impurity characterisation and identification.
• Performing protein sequence and post translational modification identification, including glycosylation analysis.
• Supporting drug substance and drug product process development by performing characterisation of process intermediates.
• Contribute to the Development of characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis.
• Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Independently testing and, increasingly, leading lines of investigation; proposing new experiments based on emerging data.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterisation

Post-translational modifications

Chromatography

Electrophoresis

Assay development

GMP knowledge

Team collaboration

Scientific presentation

Bench-based laboratory

Education

BSc. or MSc. in biochemistry, biotechnology or related discipline

PhD in related discipline

Job description

IMMUNOCORE LTD in the UK is seeking a Senior Scientist I - Characterisation to advance protein characterisation for biologics and TCR-based products. You will conduct HPLC peptide mapping and mass spectrometry-based analyses, validate PTMs, and lead characterisation campaigns for recombinant proteins across microbial and mammalian systems.

The role emphasizes independent testing, data interpretation, and collaboration with multidisciplinary teams to drive assay development and GMP-aligned work