Biologics Characterisation Scientist I

IMMUNOCORE LTD; Sutton Courtenay; On-site; GBP 65,000 - 90,000; Full time

Job summary

Immunocore Ltd in the United Kingdom is seeking a Senior Scientist I for Characterisation within CMC to advance biopharmaceuticals. You will develop and apply analytical methods, including LC-MS/MS peptide mapping and intact mass analysis, to support drug substance and product development across microbial and mammalian expression systems.

You will design stability studies, contribute to protocols and reports, and collaborate with cross-functional teams to drive efficiency and scientific

Qualifications

• Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Worked in a bench-based biopharmaceutical laboratory environment.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation thereof.
• Worked and contributed actively in a diverse team environment.
• Proposed and driven changes in working practices that have improved efficiency and supported teams through adoption and change.
• Presented detailed scientific findings and papers to internal and external audiences.

Responsibilities

• Support drug substance/product impurity characterisation and identification.
• Perform protein sequence and PTM identification, including glycosylation analysis.
• Characterise process intermediates to aid drug substance/product development.
• Develop characterisation methods for ImmTAX and related products (peptide mapping LC-MS/MS, intact mass analysis).
• Design and carry out biochemical characterisation, chemical stability and comparability studies of biologics.
• Contribute to study protocols and reports; present findings in meetings with colleagues and partners.
• Mentor others and share knowledge; provide technical guidance on equipment use.
• Maintain laboratory records and ensure compliance with EHS policies.
• Communicate results to senior management and cross-department teams.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterisation

Post-translational modification

Bench-based laboratory work

Awarded expert in electrophoretic/chro

Assay development

Stability study principles

Team collaboration

Scientific presentation

Education

BSc or MSc in biochemistry/biotechnology

PhD in related discipline

Tools

LC-MS/MS

HPLC

Job description

Immunocore Ltd in the United Kingdom is seeking a Senior Scientist I for Characterisation within CMC to advance biopharmaceuticals. You will develop and apply analytical methods, including LC-MS/MS peptide mapping and intact mass analysis, to support drug substance and product development across microbial and mammalian expression systems.

You will design stability studies, contribute to protocols and reports, and collaborate with cross-functional teams to drive efficiency and scientific