Biologics Characterisation Scientist I

IMMUNOCORE LTD; Great Rissington; On-site; GBP 65,000 - 80,000; Full time

Job summary

Immunocore Ltd. in the UK is seeking a Senior Scientist I - Characterisation to join the CMC team in Oxford.

You will contribute to characterisation of drug substances and products, develop peptide mapping methods, and advance mass spectrometry analyses to support recombinant proteins and antibodies. Focused on delivering first-in-class biotherapeutics, the role emphasizes collaboration across departments, mentoring, and advancing analytical methods in a dynamic, GMP-aware Biopharma environment.

Qualifications

• Essential: Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
• Experience of glycosylation analysis of recombinant proteins or antibodies.
• Independently coordinated extensive testing of protein biomolecules.
• Characterisation of proteins expressed in both microbial and mammalian systems.
• Understanding of expected post-translational modifications in biological systems.
• Bench-based biopharmaceutical laboratory environment experience.
• Established as an expert amongst peers in electrophoretic, chromatographic or mass spectrometry techniques.
• Experienced in assay development.
• Familiar with biopharmaceutical stability study principles and interpretation.
• Diversity and teamwork; effective communication; presenting findings.

Responsibilities

• Supporting drug substance and drug product impurity characterisation and identification
• Performing protein sequence and post translational modification identification, including glycosylation analysis.
• Supporting drug substance and drug product process development by performing characterisation of process intermediates
• Contribute to the Development of characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis
• Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
• Contribute to writing study protocols and reports.
• Independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information. Providing support on technical aspects to others.
• Priorities: establishing priorities for own work and team-based projects; making decisions on prioritisation based on the overall goals of the team, department and project, using direct evidence and personal experience as guidance.
• Technical Knowledge: sharing knowledge with the wider team and, across departments representing the department. May also act as a mentor to other colleagues, sharing scientific knowledge.
• Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard.
• Laboratory equipment: providing technical guidance to others within the team on how to use equipment most effectively.
• Reporting: communicating and presenting research findings at meetings with colleagues, senior management and partners.
• Adhere to safe working practices in laboratories according to Immunocore EHS policies.

Skills

HPLC peptide mapping

Mass spectrometry

Glycosylation analysis

Protein characterisation

Bench-based biopharmaceutical lab

Protein biomolecule testing

Team collaboration

Change management

Education

BSc or MSc in biochemistry/biotechnology or related

PhD in related discipline

Tools

HPLC

LC-MS/MS

Mass spectrometry instrumentation

Chromatography

Protein expression systems (microbial & mammalian)

Job description

Immunocore Ltd. in the UK is seeking a Senior Scientist I - Characterisation to join the CMC team in Oxford.

You will contribute to characterisation of drug substances and products, develop peptide mapping methods, and advance mass spectrometry analyses to support recombinant proteins and antibodies. Focused on delivering first-in-class biotherapeutics, the role emphasizes collaboration across departments, mentoring, and advancing analytical methods in a dynamic, GMP-aware Biopharma environment.