PostDoc Position in Extracellular Vesicle Biology (m/f/d)

Roche Holding AG; Penzberg; On-site; EUR 45,000 - 65,000; Full time

Job summary

Roche Diagnostics GmbH sucht eine/n Postdoctoral Fellow (m/w/d) zur Mitarbeit im Discovery Sciences Team. Sie arbeiten an der Analyse extrazellulärer Vesikel (EVs) und deren diagnostischem Potenzial, entwerfen, führen durch und analysieren nasslabortechnische Experimente.

In Zusammenarbeit mit Bioinformatik, Assay-Entwicklung und Sequenzierung bewerten Sie die Machbarkeit der EV-Capturing-Ansätze für Diagnostik-Plattformen.

Qualifications

• PhD in related field with 3+ years of experimental research and peer‑reviewed publications.
• Expert in EV biology, enrichment and analysis using immunoprecipitation, SEC, AF4, ELISA and Western Blot.
• Experience with RNA isolation and RNA sequencing.
• Knowledge of statistics is a plus.
• Good communication skills and fluency in English.

Responsibilities

• Perform the enrichment of EVs from human matrices, predominantly via immunoprecipitation, but also other methods like SEC, dUC and AF4.
• Analyse enriched EVs with state-of-the-art methods (mass spectrometry, RNA sequencing, luminescence) in cooperation with other departments.
• Partner with bioinformatics, assay development, and sequencing teams to evaluate the applicability of captured EVs for diagnostic platforms.
• Drive interdisciplinary meetings to share data, leverage expertise across functions, and contribute to the Diagnostics strategy.
• Document findings for patent filings and present research in stakeholder meetings, scientific journals, and international conferences.

Skills

Immunoprecipitation

SEC

AF4

ELISA

Western Blot

RNA isolation

RNA sequencing

Mass spectrometry

Luminescence assays

Englisch-Kommunikation

Education

PhD in Molecular Biology, Biochemistry, Cell Biology or related field

3+ years of experimental research experience

Tools

Mass spectrometry

RNA sequencing

Job description

Bei Roche kannst du ganz du selbst sein und wirst für deine einzigartigen Qualitäten geschätzt. Unsere Kultur fördert persönlichen Ausdruck, offenen Dialog und echte Verbindungen. Hier wirst du für das, was du bist, wertgeschätzt, akzeptiert und respektiert. Dies schafft ein Umfeld, in dem du sowohl persönlich als auch beruflich wachsen kannst. Gemeinsam wollen wir Krankheiten vorbeugen, stoppen und heilen und sicherstellen, dass jeder Zugang zur Gesundheitsversorgung hat – heute und in Zukunft. Werde Teil von Roche, wo jede Stimme zählt.

Die Position

We are looking for a highly motivated and talented Postdoctoral Fellow (m/f/d) to join our Discovery Sciences team. In this role you will be at the forefront of Science, enriching and analyzing Extracellular Vesicles (EVs) in order to deduce a diagnostic potential and address different medical needs. Your responsibilities will encompass the design, execution, and analysis of wet-lab experiments.

This position is embedded within the Discovery Sciences Chapter at Roche Diagnostics GmbH. As part of the Technology Program, you will join a high-impact team of researchers dedicated to pioneering next-generation diagnostic solutions.

Our culture is defined by trust, transparency, and a strong collaborative spirit. We are looking for a proactive colleague who balances independent critical thinking with team spirit and the flexibility to collaborate across diverse departments and interdisciplinary teams.

Your tasks

• Perform the enrichment of EVs from human matrices, predominantly via immunoprecipitation, but also other methods like SEC, dUC and AF4.
• Analysis and quality assessment of the enriched EVs with different state-of-the-art methods and technologies (targeted and untargeted like mass spectrometry, RNA sequencing, luminescence) in cooperation with other departments
• Partner with bioinformatics, assay development, and sequencing teams to evaluate the applicability of the captured EVs for diagnostic platforms.
• Drive interdisciplinary meetings to share data, leverage expertise across functions, and contribute to the broader Diagnostics strategy.
• Document findings for patent filings and present research in stakeholder meetings, scientific journals, and international conferences.

Your profile

• You have successfully completed a PhD in Molecular Biology, Biochemistry, Cell Biology or a related field including 3+ years of experimental research experience and a strong track record of peer-reviewed publications.
• You have deep expertise in the biology, enrichment and analysis of Extracellular Vesicles as well as the respective laboratory techniques, such as immunoprecipitation, size exclusion chromatography, asymmetrical flow field-flow fractionation, and immunoassays like ELISA and Western Blot,
• Your profile is complemented by proficiency in working with nucleic acids like RNA isolation and RNA sequencing.
• Your knowledge and application of statistical concepts is considered a plus
• You are goal-oriented and eager to establish new wet-lab techniques and scientific concepts
• Your personal drive and your ability to learn and take over responsibility is a key value for us.
• You possess excellent communication skills and fluency in English

This position requires handling of human fluid samples, i.e. potentially infectious material (Biosafety Level 2, “Infektionsschutzgesetz”) under company safety standards.

When does it start?

This position should be filled with effect January 2027 and is limited to 2 years.

Wer wir sind

Eine gesündere Zukunft treibt uns zur Innovation an. Mehr als 100.000 Mitarbeiter weltweit arbeiten gemeinsam daran, wissenschaftliche Fortschritte zu erzielen und sicherzustellen, dass jeder Zugang zur Gesundheitsversorgung hat – heute und für zukünftige Generationen. Durch unser Engagement werden über 26 Millionen Menschen mit unseren Medikamenten behandelt und mehr als 30 Milliarden Tests mit unseren Diagnostik-Produkten durchgeführt. Wir ermutigen uns gegenseitig, neue Möglichkeiten zu erkunden, Kreativität zu fördern und hohe Ziele zu setzen, um lebensverändernde Gesundheitslösungen zu liefern.

Gemeinsam können wir eine gesündere Zukunft gestalten.

Roche ist ein Arbeitgeber, der die Chancengleichheit fördert.