PostDoc in Precision Immunotherapy / Antibody Engineering (m/w/d)

Lmu Klinikum; München; Hybride; EUR 52 000 - 70 000; Plein temps

Résumé du poste

The Hospital of the University of Munich (LMU) invites applications for a PostDoc position in a translational immunotherapy program led by Prof. Christoph Klein. You will contribute to an AND-GATE based precision immunotherapy platform, involving engineering and purification of antibody formats and development of functional assays.

You will plan experiments, prepare data for publications and grants, and support the supervision of junior researchers in an interdisciplinary, international team.

Qualifications

• Completed PhD in biology, biochemistry, biotechnology or a comparable field.
• Solid experience in antibody engineering, protein expression and purification (e.g., FPLC).
• Molecular biology and cell biology techniques.
• iPSC cultivation/differentiation into immune cells.
• Experience with in vitro/in vivo functional assays and multi-omics data analysis is an advantage.
• The ability to work independently and in an interdisciplinary, international team.
• Excellent English skills; German skills are advantageous.

Responsabilités

• Join a translational research program in a leading group and take on potential leadership duties.
• Engage in precision immunotherapy using the AND-GATE strategy for cancer/immune cell targeting.
• Engineer, produce, and purify novel recombinant antibody formats.
• Set up and optimize in vitro and in vivo functional assays and advance iPSC organoid systems.
• Plan and coordinate experiments, prepare data for publications and grants, supervise junior researchers.

Connaissances

Antibody engineering

Protein expression

Protein purification

Molecular biology

Cell biology

iPSC cultivation

Immunotherapy

Multi-omics analysis

Independent work

English skills

Formation

PhD in Biology/ Biochemistry/ Biotechnology or comparable field

Outils

FPLC

Description du poste

PostDoc in Precision Immunotherapy / Antibody Engineering

(m/f/d)

Workplace

Working hours

Full time

Institution

Department

Research - Klein Lab at the CCRC & Gene Center LMU

Date of entry

At the earliest possible date

Swift

Reference Number

The Hospital of the University of Munich, Germany, is one of the largest and most competitive university hospitals in Germany and Europe. 48 specialized hospitals, departments and institutions harbouring excellent research and education provide patient care at the highest medical level with around 12.000 employees.

Scope of duties

As a PostDoc in the research group of Prof. Christoph Klein, you will join a translational research program and with the option to take on a leadership role.

You will be involved in a precision immunotherapy program based on an innovative conditional strategy (“AND-GATE”) to target cancer and immune cells. This includes the engineering, production and purification of novel recombinant antibody formats, the setup and optimization of in vitro and in vivo functional assays, and the further development of our iPSC-derived organoid system for patient-specific therapy testing.

You will help plan and coordinate ongoing experiments, prepare scientific data for publication and grant applications, and support the scientific supervision of junior researchers.

Our requirements

Completed PhD in Biology, Biochemistry, Biotechnology or a comparable field

• Solid experience in the following areas:
• Antibody engineering, protein expression and purification (e.g., FPLC)
• Molecular biology and cell biology techniques
• iPSC cultivation and/or differentiation into immune cell types
• Experience with in vitro or in vivo functional assays and multi-omics data analysis is an advantage
• The ability to work independently, as well as in an interdisciplinary and international team
• A structured, meticulous and solution-oriented working style
• Excellent English skills; German skills are an advantage

Our offer

The position is initially funded for two years . Subject to a positive scientific re-evaluation, an extension is possible

• An innovative and challenging position within the research group of Prof. Christoph Klein, operating at the interface of translational immunotherapy, stem cell biology and precision medicine.
• An international and interdisciplinary research environment, supported by close collaboration with academic and industrial partners within an established research network
• Close collaboration with basic scientists, bioinformaticians and clinician scientists on two complementary translational projects
• A collaborative, supportive and inspiring working environment that encourages scientific independence
• Employment according to the German public-sector collective agreement (TV-L), including annual leave and additional benefits in accordance with the applicable regulations

Disabled persons will be preferentially considered in case of equal qualification. Presentation costs cannot be refunded.

Please note that we cannot reimburse travel expenses incurred through interviews.

We ask you for your understanding that postal applications will not be returned, but will be destroyed in accordance with data protection regulations. The data usage information also applies to postal applications