PostDoc in Drug Discovery / Neutrophil-driven Inflammation (m/w/d)

Klinikum der Universität München; München; On-site; EUR 50,000 - 65,000; Full time

Job summary

Klinikum der Universität München invites applications for a PostDoc in the research group of Prof. Christoph Klein.

The position focuses on a first-in-class drug discovery project aiming to modulate neutrophil-driven inflammation. The work includes differentiation of iPSC-derived neutrophils, biochemical and cellular screening assays, and multi-omics profiling in collaboration with academic and industrial partners.

Qualifications

• PhD in Biology, Biochemistry, Biotechnology, Pharmacology or comparable field.
• Strong molecular and cell biology technique experience.
• iPSC culture/differentiation experience.
• Ability to work in interdisciplinary and international teams.
• Excellent English; German an advantage.

Responsibilities

• Perform differentiation and functional characterization of iPSC-derived neutrophils.
• Develop and execute screening assays (biochemical/cellular/HTS).
• Coordinate experiments and prepare data for publication and grant applications.
• Collaborate with academic and industrial partners; supervise junior researchers.

Skills

Molecular biology

Cell biology

iPSC culture/differentiation

Biochemical/high-throughput screening

Multi-omics analysis

Independent work

English communication

Team collaboration

Education

PhD in Biology or related field

Job description

Scope of duties

As a PostDoc in the research group of Prof. Christoph Klein, you will join a translational research program with the option to take on a leadership role. You will be involved in a first-in-class drug discovery project aimed at selectively modulating neutrophil-driven inflammation. Your work will cover the differentiation and functional characterization of iPSC-derived neutrophils, the establishment and execution of biochemical and cellular screening assays, as well as multi-omics profiling (transcriptomics, proteomics, metabolomics) in collaboration with our academic and industrial partners. You will help plan and coordinate ongoing experiments, prepare scientific data for publication and grant applications, and support the scientific supervision of junior researchers.

Our requirements

• Completed PhD in Biology, Biochemistry, Biotechnology, Pharmacology or a comparable field
• Solid experience in the following areas:
  • Molecular biology and cell biology techniques
  • iPSC cultivation and/or differentiation into immune cell types
  • Establishment and execution of biochemical, cellular or high-throughput screening assays
  • Experience with in vitro or in vivo functional assays and multi-omics data analysis is an advantage
• The ability to work independently, as well as in an interdisciplinary and international team
• A structured, meticulous and solution-oriented working style
• Excellent English skills; German skills are an advantage

Our offer

• The position is initially funded for two years . Subject to a positive scientific re-evaluation, an extension is possible
• An innovative and challenging position within the research group of Prof. Christoph Klein, operating at the interface of translational immunotherapy, stem cell biology and precision medicine.
• An international and interdisciplinary research environment, supported by close collaboration with academic and industrial partners within an established research network
• Close collaboration with basic scientists, bioinformaticians and clinician scientists on two complementary translational projects
• A collaborative, supportive and inspiring working environment that encourages scientific independence
• Employment according to the German public-sector collective agreement (TV-L), including annual leave and additional benefits in accordance with the applicable regulations