PostDoc in Molecular and Oncological Gynecology - Klinik für Frauenheilkunde und Geburtshilfe

Universitätsklinikum Frankfurt; Kelkheim (Taunus); Vor Ort; EUR 55.000 - 70.000; Vollzeit

Zusammenfassung

Ein führendes akademisches Krankenhaus in Hessen sucht einen Postdoktoranden in der molekularen und onkologischen Gynäkologie. Die Position umfasst die Forschung zur Reaktivierung von Tumorsuppressorgenen in der Krebsbehandlung. Der ideale Kandidat hat umfassende Erfahrung in der Forschung und Kenntnisse in der Arbeit mit Mausmodellen. Teilzeitarbeit und Kinderbetreuung werden angeboten, um die Vereinbarkeit von Beruf und Familie zu fördern.

Leistungen

Attraktive Vergütung gemäß Tarifvertrag

Betriebliche Altersvorsorge

Fortbildungsmöglichkeiten

Gesundheitsangebote

Kostenlose öffentliche Verkehrsmittel in Hessen

Kitaplätze für Kinder

Qualifikationen

• Forschungserfahrung in der Onkologie.
• Kenntnisse über IVT-mRNA und therapeutische Ansätze.
• Praktische Erfahrung mit Mausmodellen.

Aufgaben

• Durchführung von Forschungsarbeiten zur Reaktivierung von Tumorsuppressorgenen.
• Experimente an Mausmodellen zur Tumorreaktion.
• Entwicklung von Organoid-Kulturen.

Kenntnisse

Forschungskompetenz

Kenntnisse zu IVT-mRNA

Umgang mit Mausmodellen

Biolumineszenz-Bildgebung

Kenntnisse in Kombinationstherapien

Ausbildung

Doktorgrad in Biomedizin oder verwandtem Feld

FELASA-Zertifikat

Jobbeschreibung

The Department of Molecular and Oncological Gynecology at the University Hospital Frankfurt invites applications for a Postdoctoral Researcher position at earliest possible time to join an innovative project investigating IVT‑mRNA-based reactivation of tumor suppressor pathways in ovarian cancer.

The position is located in a dynamic and collaborative research environment focusing on novel therapeutic strategies to overcome drug resistance in high-grade serous ovarian cancer. The project centers on the development and preclinical validation of next‑generation lipid nanoparticle (LNP) carriers for IVT‑mRNA delivery, both functionalized and non‑functionalized with antibodies. These systems will be evaluated in patient‑derived organoids and in vivo, using orthotopic and metastatic ovarian cancer mouse models, including PDX models, with the aim to improve targeted therapy and translational application.

Genau hier sind Sie mittendrin in der Medizin von morgen. Die Universitätsmedizin Frankfurt gehört zu den führenden Universitätskliniken in Deutschland. Bei uns ziehen über 8.500 Menschen aus über 100 Nationen an einem Strang. Aus Wissen wird Gesundheit - das ist dabei unser täglicher Antrieb. Denn wir verbinden Krankenversorgung mit Forschung und Lehre, begrüßen den Fortschritt und entwickeln uns selbst immer weiter. So leisten wir einen wichtigen Beitrag für die Gesundheit und die Lebensqualität von über 500.000 Patientinnen und Patienten jährlich: kompetent, gewissenhaft und mit Leidenschaft.

PostDoc in Molecular and Oncological Gynecology – Klinik für Frauenheilkunde und Geburtshilfe. Andere Berufsbereiche: Forschung, Lehre, Deutschland, Gesundheit, soziale Dienste, Healthcare. Phone: 069‑6301‑6894.

We welcome applications from candidates of all genders. Women are currently underrepresented in these positions at Universitätsmedizin Frankfurt. Therefore, applications from women are especially encouraged. Applicants with severe disabilities will be given preferential consideration in cases of equal personal and professional qualifications.

Conduct in-depth research into the role of IVT‑mRNA in the restoration of tumorsuppressor genes in ovarian cancer and reversing therapy resistance.

Perform mouse model experiments, including tumor induction, in vivo drug treatment, and assessment of tumor response using bioluminescence imaging.

The development of patient‑derived organoid cultures.

Perform functional assays to assess cell viability, proliferation, apoptosis, and drug sensitivity in cancer models.

Develop and implement innovative therapeutic strategies, including combination treatments with targeted IVT‑mRNA and cis‑platin.

Collaborate with a multidisciplinary team of researchers and clinicians to interpret experimental results and drive the research forward.

Expertise in working with different mouse models, including tumor injection, i.p., i.v. treatment of mice, and in vivo treatments.

Expertise in working with bioluminescence‑based tumor imaging in vivo is highly desirable.

FELASA Certificate is mandatory for the position.

Knowledge of oncological therapeutic approaches, including combination therapies and targeted inhibition.

Due to legal regulations, valid proof of measles immunity/vaccination is required.

Responsibilities

• Conduct in-depth research into the role of IVT‑mRNA in the restoration of tumorsuppressor genes in ovarian cancer and reversing therapy resistance.
• Perform mouse model experiments, including tumor induction, in vivo drug treatment, and assessment of tumor response using bioluminescence imaging.
• The development of patient‑derived organoid cultures.
• Perform functional assays to assess cell viability, proliferation, apoptosis, and drug sensitivity in cancer models.
• Develop and implement innovative therapeutic strategies, including combination treatments with targeted IVT‑mRNA and cis‑platin.
• Collaborate with a multidisciplinary team of researchers and clinicians to interpret experimental results and drive the research forward.

Benefits

• In addition to an attractive salary based on a collective agreement with an annual special payment, you benefit from long‑term security through company pension schemes.
• Internal and external training for your professional development.
• Benefit from our attractive health offers: we offer regular online and face‑to‑face courses on nutrition, relaxation, sports and exercise.
• Part‑time employment is possible; we offer childcare in our daycare centre (if you have any questions, please contact UKF‑Familienservice) and childcare during holidays.
• Free public transport in all Hessen (Free State Ticket Hessen).
• Uniklinik‑Campus, Mensa, Cafés.
• Insights: Instagram, YouTube, LinkedIn.
• FAQ'S for new employees.

Uniklinik, Universitätsklinikum, Universitätsmedizin, Krankenhaus, Gesundheitswesen, Aushilfe, Student, Studierende, Neurologie.