Senior Scientist, Protein Analytics & Biophysics (Equity)

Generate Biomedicines; Somerville (MA); On-site; USD 120,000 - 180,000; Full time

Job summary

Generate Biomedicines seeks a Senior Scientist I to lead analytical and biophysical workflows within Protein Analytics & Biophysics. You will drive stability, aggregation, and developability assessments, and guide mass spectrometry and SPR-based analyses while collaborating across discovery teams.

The role emphasizes hands-on work, method development, and scientific leadership in an interdisciplinary environment supported by machine-learning-enabled discovery efforts.

Qualifications

• Ph.D. in biochemistry/biophysics/analytical chemistry or related field with 4+ years of relevant research.
• Hands-on biophysical characterization including stability, aggregation, developability assessment.
• Experience with protein separation science and chromatography (SEC, IEX, HIC, capillary electrophoresis).
• SPR binding experience strongly preferred; BLI or affinity assays also valuable.
• Experience with mass spectrometry, proteomics, or related technologies; willingness to learn more.
• Ability to independently plan experiments, troubleshoot workflows, and interpret data.
• Proven method development and cross-functional collaboration skills.
• Strong written and oral communication; ability to mentor colleagues.

Responsibilities

• Lead hands-on analytical and biophysical workflows for protein quality and developability.
• Develop, optimize, and troubleshoot separation workflows for characterization.
• Perform binding analyses with emphasis on SPR and related technologies.
• Contribute to MS workflows to characterize identity, mass, heterogeneity, and modifications.
• Apply principles to new sample types and project questions; design appropriate controls.
• Collaborate with project teams to define plans, communicate results, and guide decisions.
• Provide technical leadership and mentoring on methods and workflows.
• Maintain and troubleshoot laboratory instrumentation and platforms.
• Contribute to emerging approaches at the interface of analytics, ML, and discovery.

Skills

Biophysical characterization

Protein separation

SPR binding

Mass spectrometry

Molecular barcoding

Machine learning data integration

Experiment design

Cross-functional collaboration

Mentoring

Education

Ph.D. in biochemistry/biophysics/analytical chemistry or related field

M.S. with 8+ years of relevant experience

Tools

SEC

IEX

HIC

Capillary electrophoresis

Mass spectrometry

Proteomics

Molecular barcoding

Machine learning data integration

Job description

Generate Biomedicines seeks a Senior Scientist I to lead analytical and biophysical workflows within Protein Analytics & Biophysics. You will drive stability, aggregation, and developability assessments, and guide mass spectrometry and SPR-based analyses while collaborating across discovery teams.

The role emphasizes hands-on work, method development, and scientific leadership in an interdisciplinary environment supported by machine-learning-enabled discovery efforts.