Senior Scientist I, Protein Analytics & Biophysics

Generate Biomedicines; Somerville (MA); On-site; USD 120,000 - 180,000; Full time

Job summary

Generate Biomedicines seeks a Senior Scientist I to lead analytical and biophysical workflows within Protein Analytics & Biophysics. You will drive stability, aggregation, and developability assessments, and guide mass spectrometry and SPR-based analyses while collaborating across discovery teams.

The role emphasizes hands-on work, method development, and scientific leadership in an interdisciplinary environment supported by machine-learning-enabled discovery efforts.

Qualifications

• Ph.D. in biochemistry/biophysics/analytical chemistry or related field with 4+ years of relevant research.
• Hands-on biophysical characterization including stability, aggregation, developability assessment.
• Experience with protein separation science and chromatography (SEC, IEX, HIC, capillary electrophoresis).
• SPR binding experience strongly preferred; BLI or affinity assays also valuable.
• Experience with mass spectrometry, proteomics, or related technologies; willingness to learn more.
• Ability to independently plan experiments, troubleshoot workflows, and interpret data.
• Proven method development and cross-functional collaboration skills.
• Strong written and oral communication; ability to mentor colleagues.

Responsibilities

• Lead hands-on analytical and biophysical workflows for protein quality and developability.
• Develop, optimize, and troubleshoot separation workflows for characterization.
• Perform binding analyses with emphasis on SPR and related technologies.
• Contribute to MS workflows to characterize identity, mass, heterogeneity, and modifications.
• Apply principles to new sample types and project questions; design appropriate controls.
• Collaborate with project teams to define plans, communicate results, and guide decisions.
• Provide technical leadership and mentoring on methods and workflows.
• Maintain and troubleshoot laboratory instrumentation and platforms.
• Contribute to emerging approaches at the interface of analytics, ML, and discovery.

Skills

Biophysical characterization

Protein separation

SPR binding

Mass spectrometry

Molecular barcoding

Machine learning data integration

Experiment design

Cross-functional collaboration

Mentoring

Education

Ph.D. in biochemistry/biophysics/analytical chemistry or related field

M.S. with 8+ years of relevant experience

Tools

SEC

IEX

HIC

Capillary electrophoresis

Mass spectrometry

Proteomics

Molecular barcoding

Machine learning data integration

Job description

Generate Biomedicines is looking for a talented Senior Scientist I to join the Protein Analytics & Biophysics team within Protein Sciences.

This role will lead and contribute to analytical characterization, separation science, and biophysical workflows that assess protein quality, stability, developability, and molecular interactions in support of discovery programs and Generate Biomedicines’ machine learning-powered platform. The successful candidate will bring broad technical expertise, strong scientific judgment, and the ability to represent Protein Analytics & Biophysics on cross‑functional project teams.

The role is hands‑on and collaborative, with responsibility for advancing methods, developing fit‑for‑purpose workflows, troubleshooting complex experiments, interpreting data, and helping the team respond to evolving program and platform needs. The position also offers opportunities to contribute to novel technologies at the interface of protein analytics, molecular barcoding, mass spectrometry, and machine‑learning‑enabled discovery.

Here’s how you will contribute:

• Lead and execute hands‑on analytical and biophysical workflows to assess protein stability, aggregation, self‑association, polyreactivity, and other developability attributes.
• Develop, optimize, and troubleshoot separation workflows for protein characterization, including chromatography and related separation methods.
• Perform and expand binding analyses, with a strong emphasis on SPR and related kinetic or affinity‑based technologies.
• Contribute to mass spectrometry workflows that characterize protein identity, molecular mass, heterogeneity, and modifications, and support integration of MS data with biophysical and separation‑based measurements.
• Apply scientific principles creatively to develop and adapt methods for new sample types, protein formats, assay conditions, and project questions.
• Design experiments, establish appropriate controls, interpret data, and recommend follow‑up studies with increasing independence.
• Work directly with project teams to define analytical plans, generate project data, communicate results and limitations, and support scientific decisions.
• Serve as a technical and strategic representative for Protein Analytics & Biophysics on assigned projects and contribute to cross‑functional discussions and planning.
• Provide technical leadership within assigned methods, including leading method‑development efforts, evaluating new assays, improving workflows, and helping establish best practices.
• Operate, maintain, and troubleshoot relevant laboratory instrumentation and automated platforms.
• Contribute to emerging approaches involving molecular barcoding, mass spectrometry, proteomics, and machine‑learning‑enabled data integration as program needs evolve.
• Support training, knowledge sharing, documentation, and continuous improvement within Protein Analytics & Biophysics.
• Collaborate closely with scientists across Protein Sciences, Technology, computational and machine‑learning teams, and other partner functions in a fast‑paced, interdisciplinary environment.

The Ideal Candidate will have:

• Ph.D. in biochemistry, biophysics, analytical chemistry, protein science, or a related discipline with 4+ years of relevant research experience; or M.S. with 8+ years of relevant experience; equivalent experience may be considered.
• Strong hands‑on expertise in biophysical characterization of proteins, including stability, aggregation, self‑association, polyreactivity, or related developability assessments.
• Practical experience with protein separation science and chromatography, such as SEC, IEX, HIC, capillary electrophoresis, or related methods.
• Experience with SPR or related binding technologies is strongly preferred; experience with BLI or other kinetic and affinity‑based assays is also valuable.
• Experience with general mass spectrometry, proteomics, structural mass spectrometry, molecular barcoding, or related technologies is preferred; a willingness to develop these skills is also valued.
• Demonstrated ability to independently plan experiments, troubleshoot complex workflows, interpret data, and recommend next steps.
• Demonstrated method‑development experience, including the ability to apply established scientific principles creatively to address new analytical questions or improve existing workflows.
• Ability to represent a technical and strategic function on cross‑functional project teams and communicate scientific conclusions, risks, and recommendations clearly.
• Experience providing technical guidance, mentoring colleagues, or leading method and workflow improvements.
• Interest in working at the interface of experimental protein analytics, data science, and machine‑learning‑enabled discovery is valuable.
• Willingness to learn new assays and instrumentation and remain actively engaged in laboratory work.
• Strong documentation, organization, written communication, and collaboration skills.

About Generate Biomedicines

We are a clinical‑stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creation—one grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large‑scale experimentation, this approach aims to reduce the uncertainty, time, and cost associated with developing protein‑based medicines.

Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical‑stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

At Generate:Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies

Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

Compensation:

The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job‑related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.