Senior Scientist, Cell-Based Kinase Assays

St. Jude Children's Research Hospital, Inc.; Memphis (TN); On-site; USD 104,000 - 186,000; Full time

Job summary

St. Jude Children's Research Hospital, Memphis, TN, seeks an experienced cell biologist to join the Blue Sky Kinases initiative.

You will apply molecular biology, biochemistry, and cell culture to study kinase structure and regulation, translating in vitro findings to cellular function. You will help optimize cell‑based assays across multiple platforms and contribute to high‑throughput inhibitor analyses, collaborating with the Cell‑Based Assays team and external partners to advance kinase

Qualifications

• Bachelor's degree in a relevant scientific area is required.
• Five (5) years of relevant work experience is required with a PhD.
• Eight (8) years of relevant experience is required with a Master's Degree.
• Ten (10) years of relevant work experience is required with a Bachelor's Degree.

Responsibilities

• Research kinase‑mediated signaling pathways and cellular outcomes of projects.
• Identify cellular assays and cells for structure‑guided analysis of kinase signaling.
• Develop strategies for cell‑based assays including protein phosphorylation, interaction, localization, RNA abundance, ubiquitination, and protein abundance.
• Develop strategies for cell‑based phenotypic assays including viability, apoptosis, autophagy, migration, or differentiation.
• Perform optimization and troubleshooting of cell‑based assays.
• Perform statistical analysis using graphing software or R.
• Interpret and communicate results within the team and with collaborators.

Skills

Cell culture

Kinase signaling

Molecular biology

Biochemistry

Data analysis (R / statistics)

Education

Bachelor's degree in life sciences

PhD (preferred) or 5+ years experience with MS

MS degree with 8+ years experience

BS with 10+ years experience

Tools

PCR

Western blotting

Cloning

qRT‑PCR

Flow cytometry

Job description

St. Jude Children's Research Hospital, Memphis, TN, seeks an experienced cell biologist to join the Blue Sky Kinases initiative.

You will apply molecular biology, biochemistry, and cell culture to study kinase structure and regulation, translating in vitro findings to cellular function. You will help optimize cell‑based assays across multiple platforms and contribute to high‑throughput inhibitor analyses, collaborating with the Cell‑Based Assays team and external partners to advance kinase