Senior Cell Assay Lead, Kinase Signaling

St. Jude Children's Research Hospital, Inc.; Memphis (TN); On-site; USD 138,000 - 262,000; Full time

Job summary

St. Jude Children's Research Hospital in Memphis, TN, seeks an experienced Senior Scientist to join the Blue Sky Kinases initiative.

The role focuses on translating kinase structure and regulation findings into functional cellular outcomes, guiding junior staff, and integrating diverse cell-based assays across multiple kinases. You will lead high-quality cell biology experiments, critically review data, troubleshoot assays, and collaborate with cell-based and structural biology teams to advance

Qualifications

• Bachelor's degree in a relevant scientific area required.
• PhD preferred for advanced responsibilities.
• Experience leading cell biology projects and mentoring junior staff.

Responsibilities

• Research kinase-mediated signaling pathways and cellular outcomes for assigned kinase projects.
• Interface with cell-based assays team and structural biology researchers to select appropriate cellular assays.
• Develop strategies for implementing a wide spectrum of cell-based assays, including phosphorylation, protein localization, and RNA analyses.
• Lead and mentor a team of scientists on structure-guided cell biology projects.
• Troubleshoot cell-based phenotypic assays such as viability, apoptosis, autophagy, and differentiation.
• Review relevant literature and experimental data to inform assay optimization.
• Perform data analyses and statistical assessments using software tools.
• Prepare research reports and communicate results within teams and collaborators.
• Contribute to recruiting and growing the team.

Skills

Kinase signaling analysis

Cell culture

Protein expression

Data analysis

Presentation skills

Mouse models

Education

Bachelor's degree required

PhD preferred

Tools

qRT-PCR

Western blotting

Flow cytometry

Immunoprecipitation

Confocal microscopy

Job description

St. Jude Children's Research Hospital in Memphis, TN, seeks an experienced Senior Scientist to join the Blue Sky Kinases initiative.

The role focuses on translating kinase structure and regulation findings into functional cellular outcomes, guiding junior staff, and integrating diverse cell-based assays across multiple kinases. You will lead high-quality cell biology experiments, critically review data, troubleshoot assays, and collaborate with cell-based and structural biology teams to advance