Senior Kinase Research Lead, Protein Technologies Center

St. Jude Children's Research Hospital; Memphis (TN); On-site; USD 60,000 - 105,000; Full time

Job summary

St. Jude Children’s Research Hospital in Memphis, TN, invites a Lead Researcher to advance studies in the human protein kinome as part of the Blue Sky Initiative.

The role focuses on molecular biology, biochemistry, biophysics, and structural biology to uncover kinase mechanisms and new therapeutic opportunities. The successful candidate will prepare high-quality proteins from bacteria, insect, and mammalian systems for NMR, crystallography, and cryo-EM studies while collaborating across core

Qualifications

• Bachelor’s degree in a relevant scientific area is required.
• 5+ years of research experience with a Bachelor's.
• 3+ years of experience with a Master’s degree.
• No prior experience required with a PhD.

Responsibilities

• Independently perform and lead molecular cloning and protein purification experiments
• Biophysically characterize the proteins and perform various biochemical assays
• Screen protein crystals for X-ray crystallography and freeze grids for Cryo-EM
• Handle insect and mammalian cell cultures for protein production
• Experience with at least one structural biology technique, such as cryo-EM or X-ray crystallography, and the ability to refine, model-build, and interpret protein structures
• Analyze and interpret experimental data and prioritize experiments for structural studies
• Maintain comprehensive and well-organized experimental records

Skills

Molecular cloning

Protein purification

Biophysical characterization

Cryo-EM

Education

Bachelor’s degree in a relevant scientific area

Master’s degree

PhD

Job description

St. Jude Children’s Research Hospital in Memphis, TN, invites a Lead Researcher to advance studies in the human protein kinome as part of the Blue Sky Initiative.

The role focuses on molecular biology, biochemistry, biophysics, and structural biology to uncover kinase mechanisms and new therapeutic opportunities. The successful candidate will prepare high-quality proteins from bacteria, insect, and mammalian systems for NMR, crystallography, and cryo-EM studies while collaborating across core