Senior Protein Engineering Scientist — Gene Editing Platforms

Arbor Biotechnologies; Cambridge (MA); On-site; USD 95,000 - 110,000; Full time

Benefits offered by this job

Bonus

New hire equity

Parental leave (12 weeks)

Job summary

Arbor Biotechnologies in Cambridge, MA is seeking an experienced molecular biologist to lead and optimize experiments for protein engineering campaigns. You will generate mutants, run cell-based assays, and evaluate variants for genome editing applications.

You will design AAV, IVT mRNA workflows, and sequencing analyses; work across multiple projects, communicate results to teams, and help shape our editing strategies.

Qualifications

• Hands-on molecular biology, cell-based assays, and protein variant evaluation.
• Experience in tissue culture and gene editing contexts.
• Experience with AAV or IVT mRNA workflows is preferred.
• Ability to manage multiple experiments and troubleshoot.

Responsibilities

• Execute and optimize molecular biology and cell-based experiments for protein engineering campaigns.
• Generate and evaluate protein mutants and variants for genome editing applications.
• Run cell-based screening workflows including transient transfection and transduction in various cell models.
• Design, package, and test AAVs for variant evaluation.
• Synthesize, purify, and test IVT-generated mRNA and prepare sequencing libraries.

Skills

Molecular biology

Cell-based assays

Protein variant evaluation

Education

Bachelor’s degree in biology / biochemistry / molecular biology

Master’s degree in related field

Tools

AAV production

IVT mRNA workflows

Sequencing library prep

Nucleofection

Job description

Arbor Biotechnologies in Cambridge, MA is seeking an experienced molecular biologist to lead and optimize experiments for protein engineering campaigns. You will generate mutants, run cell-based assays, and evaluate variants for genome editing applications.

You will design AAV, IVT mRNA workflows, and sequencing analyses; work across multiple projects, communicate results to teams, and help shape our editing strategies.