Senior Protein Engineering Scientist, Genome Editing

Arbor Biotechnologies Inc; Cambridge (MA); On-site; USD 95,000 - 110,000; Full time

Benefits offered by this job

Bonus eligibility

New hire equity

12 weeks parental leave

Paid parking or transit

401(k) match

Discretionary time off

Job summary

Arbor Biotechnologies, a clinical stage gene editing company based in Cambridge, MA, is advancing genomic medicines with a focus on ALS targets. This role contributes to protein engineering campaigns by generating and testing variants.

You will run molecular biology and cell-based screening workflows across AAV, IVT mRNA, and sequencing readouts; design and test AAVs; prepare sequencing libraries; and communicate findings to project teams. The base salary ranges and benefits are outlined.

Qualifications

• Hands-on molecular biology, cell-based assay, and protein variant evaluation work.
• Tissue culture experience including transient transfection, nucleofection, or transduction.
• Managed multiple experiments or workstreams with general guidance.
• Troubleshoot independently, analyze results, document carefully, and explain findings clearly.
• Preferred: AAV production, IVT mRNA workflows, sequencing library prep, or cell-based editing assays.
• Plus: CRISPR or other gene editing technologies; Illumina sequencing workflows.

Responsibilities

• Execute and optimize molecular biology experiments supporting protein engineering campaigns.
• Run cell-based screening workflows, including transient transfection, nucleofection, and transduction.
• Design, package, and test AAVs for variant evaluation.
• Synthesize, purify, characterize, and test IVT-generated mRNA.
• Prepare sequencing libraries and support analysis of editing outcomes.
• Interpret data, summarize findings, and communicate results clearly to project teams.
• Recommend follow-up experiments, controls, and workflow improvements.
• Keep accurate records and prepare data summaries for cross-functional review.

Skills

Molecular biology

Cell-based assays

Protein variant evaluation

Tissue culture

Troubleshooting

CRISPR gene editing

Illumina sequencing workflows

Education

Bachelor’s degree in biology/biochemistry/molecular biology or related field

Master’s degree with 3+ years of experience

Tools

Illumina sequencing workflows

AAV production

IVT mRNA workflows

Sequencing library prep

Job description

Arbor Biotechnologies, a clinical stage gene editing company based in Cambridge, MA, is advancing genomic medicines with a focus on ALS targets. This role contributes to protein engineering campaigns by generating and testing variants.

You will run molecular biology and cell-based screening workflows across AAV, IVT mRNA, and sequencing readouts; design and test AAVs; prepare sequencing libraries; and communicate findings to project teams. The base salary ranges and benefits are outlined.