Senior In Vivo Pharmacology Associate | Gene Editing Programs

Arbor-Biotechnologies-Inc; Cambridge (MA); On-site; USD 85,000 - 95,000; Full time

Job summary

Arbor Biotechnologies Inc. in Cambridge, MA is seeking a hands-on In Vivo Pharmacology Scientist to drive rodent studies from dosing through tissue collection and molecular readouts. You will generate data that informs preclinical progress and IND-enabling work, reporting to the Senior Scientist, In Vivo Pharmacology.

On-site in Cambridge, typically 4-5 days a week. The role requires performing dosing, sample collection, and tissue processing, plus molecular assays like qPCR, RNAscope, ELISA,

Qualifications

• Bachelor's degree in pharmacology, biology, neuroscience, molecular biology, or a related field with 3+ years of industry experience, or a master's degree with 1+ year.
• Has run in vivo rodent studies hands-on, including dosing, monitoring, blood collection, tissue harvest, and necropsy.
• Has dosed rodents by intravenous, retro-orbital, or comparable routes.
• Has processed animal tissues and biological samples for molecular, biochemical, or pharmacodynamic endpoints.
• Has run molecular and biochemical assays such as qPCR/ddPCR, RT-qPCR, Western blot, Simple Western/Jess, ELISA, or RNAscope; flow cytometry experience preferred.
• Has managed
• Has supported IND-enabling studies (preferred).

Responsibilities

• Run in vivo pharmacology studies in rodents, including dosing, monitoring, clinical observations, blood collection, tissue harvest, and necropsy.
• Set up and schedule studies, and coordinate between the laboratory and the animal facility.
• Process tissues and biological samples, and isolate DNA, RNA, and protein for molecular, biochemical, and pharmacodynamic analysis.
• Run assays such as qPCR/ddPCR, RT-qPCR, Western blot, Simple Western/Jess, ELISA, or RNAscope.
• Analyze, interpret, and graph study and assay data in GraphPad Prism and other analysis tools.
• Present findings, study progress, and data summaries to project teams and cross-functional collaborators.
• Keep study records, sample inventories, and protocols accurate and current.

Skills

In vivo pharmacology

Rodent dosing

Sample collection

Molecular analysis

Data analysis

Education

Bachelor's degree in pharmacology/biology/neuroscience/molecular biology

Master's degree in related field

Tools

qPCR/ddPCR

RT-qPCR

Western blot

ELISA

RNAscope

Simple Western/Jess

Flow cytometry

Job description

Arbor Biotechnologies Inc. in Cambridge, MA is seeking a hands-on In Vivo Pharmacology Scientist to drive rodent studies from dosing through tissue collection and molecular readouts. You will generate data that informs preclinical progress and IND-enabling work, reporting to the Senior Scientist, In Vivo Pharmacology.

On-site in Cambridge, typically 4-5 days a week. The role requires performing dosing, sample collection, and tissue processing, plus molecular assays like qPCR, RNAscope, ELISA,