Protein Engineering Scientist, Genome Editing (Equity)

Arbor; Cambridge (MA); On-site; USD 95,000 - 110,000; Full time

Job summary

Arbor Biotechnologies in Cambridge, MA is seeking a hands-on molecular biologist to drive protein engineering campaigns. You will generate and test protein variants, run cell-based screens, and help optimize delivery and assay performance across AAV, IVT mRNA, and sequencing readouts.

The role demands strong experience in molecular biology and tissue culture, with a track record of managing multiple experiments.

Qualifications

• Bachelor’s degree in biology, biochemistry, molecular biology, or a related field with 5+ years of relevant experience, or a Master’s with 3+ years.
• Hands-on molecular biology, cell-based assay, and protein variant evaluation work.
• Tissue culture experience, including transient transfection, nucleofection, or transduction.
• Managed multiple experiments or workstreams with general guidance.
• Preferred: AAV production, IVT mRNA workflows, sequencing library prep, or cell-based editing assays.
• Plus: CRISPR or other gene editing technologies; Illumina sequencing workflows.

Responsibilities

• Execute and optimize molecular biology and cell-based experiments supporting protein engineering campaigns, troubleshooting production, delivery, and assay performance as issues arise.
• Generate and evaluate protein mutants and variants for genome editing applications.
• Run cell-based screening workflows, including transient transfection, nucleofection, and transduction in dividing and non-dividing cell models.
• Design, package, and test AAVs for variant evaluation.
• Synthesize, purify, characterize, and test IVT-generated mRNA.
• Prepare sequencing libraries and support analysis of editing outcomes, variant performance, and assay quality.
• Interpret data, summarize findings, and communicate results clearly to project teams.
• Recommend follow-up experiments, controls, and workflow improvements.
• Keep accurate records and prepare data summaries for cross-functional review.
• Partner with upstream design and downstream testing teams on planning, prioritization, and handoff.

Skills

Molecular biology

Cell-based assays

Protein variant evaluation

CRISPR / gene editing

Illumina sequencing

Education

Bachelor’s degree in biology or related field

Master’s degree in biology or related field

Tools

AAV production

IVT mRNA workflows

Sequencing library prep

Tissue culture equipment

Job description

Arbor Biotechnologies in Cambridge, MA is seeking a hands-on molecular biologist to drive protein engineering campaigns. You will generate and test protein variants, run cell-based screens, and help optimize delivery and assay performance across AAV, IVT mRNA, and sequencing readouts.

The role demands strong experience in molecular biology and tissue culture, with a track record of managing multiple experiments.