Senior LNP Production Scientist - Preclinical

Flagship Pioneering, Inc.; Cambridge (MA); On-site; USD 81,000 - 107,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Job summary

Mirai Bio, a private biotechnology company backed by Flagship Pioneering, is seeking a Research Associate II/Senior Research Associate, LNP Production to advance lipid nanoparticle formulations for nucleic acid therapeutics. You will design, produce, and optimize LNPs for preclinical research across multiple programs, applying rigorous methods and strong scientific judgment.

The role requires hands-on experience with LNP formulation, scalable production, and cross-functional collaboration to

Qualifications

• BS or MS in chemical engineering, biochemical engineering, pharmaceutical sciences, chemistry, biology, or a related scientific discipline.
• RA II: BS + 2-4 years or MS + 0-2 years of relevant industry or research experience.
• SRA: BS + 5 years or MS + 3 years of relevant industry or research experience.
• Hands-on experience with lipid nanoparticle formulation and production, particularly for nucleic acid cargos such as mRNA, siRNA, or other genetic medicines.
• Experience with a range of LNP processing techniques and equipment across multiple scales, including mixers, pumping systems, TFF, and related unit operations.
• Familiarity with common analytical techniques used to characterize LNPs, including measurements of particle size, polydispersity, encapsulation efficiency, and other relevant physicochemical attributes.
• Demonstrated ability to independently execute experiments, troubleshoot technical challenges, interpret data, and drive projects forward.
• Strong organizational, written, and verbal communication skills.
• Collaborative and adaptable team player who is equally comfortable working independently and partnering across functions.
• Ability to prioritize effectively and consistently deliver high-quality results in a fast-paced, dynamic environment.

Responsibilities

• Design, formulate, produce, and characterize LNPs to support preclinical research for internal platform and external partnerships.
• Execute LNP production across a range of process scales, from small-scale formulation and process optimization through larger-scale production.
• Operate and develop processes using relevant LNP manufacturing and process-development equipment, including mixers, pumping systems, tangential flow filtration (TFF), and related technologies.
• Troubleshoot formulation and process challenges and contribute to the optimization and continuous improvement of LNP production processes.
• Collaborate closely with scientists and cross-functional teams to design experiments, interpret results, and advance program objectives.
• Support the development and implementation of robust, reproducible LNP production and characterization workflows.
• Maintain accurate and thorough documentation of experimental procedures, results, and conclusions in electronic laboratory notebooks.
• Analyze and communicate experimental results and present findings and recommendations to cross-functional teams.
• Contribute to a culture of scientific rigor, collaboration, continuous learning, and operational excellence.

Skills

lipid nanoparticle formulation

LNP production

analytical techniques

troubleshooting

data interpretation

communication

Education

BS/MS in chemical/biochemical/pharmaceutical sciences

Tools

LNP processing equipment (mixers, pumping systems)

tangential flow filtration (TFF)

Job description

Mirai Bio, a private biotechnology company backed by Flagship Pioneering, is seeking a Research Associate II/Senior Research Associate, LNP Production to advance lipid nanoparticle formulations for nucleic acid therapeutics. You will design, produce, and optimize LNPs for preclinical research across multiple programs, applying rigorous methods and strong scientific judgment.

The role requires hands-on experience with LNP formulation, scalable production, and cross-functional collaboration to