Preclinical RNA/LNP Manufacturing Associate II

Sail Biomedicines, Inc.; Cambridge (MA); On-site; USD 75,000 - 100,000; Full time

Benefits offered by this job

Competitive salary

Equal opportunity employer

Job summary

Sail Biomedicines in Cambridge, MA is seeking a Research Associate II to join the Preclinical Manufacturing team, supporting production of RNA cargo molecules and lipid nanoparticle (LNP) drug substances and drug products. This hands-on role requires meticulous execution and cross-functional collaboration to advance scalable RNA/LNP processes.

You will operate lab-scale instrumentation (AKTA/FPLC, TFF, PCR, HPLC, UV-Vis, capillary electrophoresis, and light scattering), perform analytical

Qualifications

• BS with 2+ years industry experience or MS in Molecular Biology, Biochemistry, Biochemical Engineering, or related field.
• Hands-on experience in RNA/DNA production and purification.
• LNP formulation and characterization.
• Chromatography (AKTA/FPLC, HPLC).
• Tangential flow filtration (TFF).
• Automated liquid handling systems.
• Strong experimental design, data analysis, and technical documentation.
• Experience with analytical methods such as capillary electrophoresis, UV-Vis, or light scattering preferred.

Responsibilities

• Support the production of RNA cargo molecules and lipid nanoparticle (LNP) formulations for preclinical studies.
• Execute hands-on laboratory work involving eRNA synthesis, purification, and LNP encapsulation.
• Contribute to the development, optimization, and scale-up of high-yield, high-quality RNA/LNP processes.
• Operate and maintain lab-scale instrumentation, including AKTA (FPLC), TFF systems, PCR, HPLC, capillary electrophoresis, UV-Vis, and light scattering platforms.
• Perform analytical characterization and quantification of RNA and other nucleic acids.
• Analyze experimental data and document results in electronic lab notebooks (ELN) and technical reports.
• Collaborate cross-functionally with research, analytical, and process development teams to support project goals.

Skills

RNA/DNA production

LNP formulation

Chromatography

Tangential flow filtration

Automated liquid handling

Experimental design

Aseptic technique

Data analysis

Technical documentation

Education

BS in Molecular Biology/Biochemistry/Biochemical Engineering

MS in Molecular Biology/Biochemistry/Biochemical Engineering

Tools

AKTA/FPLC

HPLC

TFF systems

PCR

UV-Vis

Capillary electrophoresis

Light scattering

Job description

Sail Biomedicines in Cambridge, MA is seeking a Research Associate II to join the Preclinical Manufacturing team, supporting production of RNA cargo molecules and lipid nanoparticle (LNP) drug substances and drug products. This hands-on role requires meticulous execution and cross-functional collaboration to advance scalable RNA/LNP processes.

You will operate lab-scale instrumentation (AKTA/FPLC, TFF, PCR, HPLC, UV-Vis, capillary electrophoresis, and light scattering), perform analytical