Senior Director, LNP Formulation & Process Innovation

Flagship Pioneering, Inc.; Cambridge (MA); On-site; USD 213,000 - 281,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Broad range of other benefits

Job summary

Mirai Bio is seeking an experienced Senior Director of Lipid Nanoparticle (LNP) Formulation & Process Development to lead LNP formulation, process development, and small-scale production for partner and internal programs in Cambridge, MA. The role blends scientific leadership with client engagement to advance multiple preclinical programs.

The candidate will drive strategy, build scalable operations, and mentor a growing team, ensuring high-quality formulations and successful technology transfer

Qualifications

• Ph.D. in Pharmaceutical Sciences, Chemical Engineering, Bioengineering, Chemistry, Biochemistry, or related field with 12+ years of industry experience; M.S. with 14+ years; or B.S. with 16+ years.
• Extensive hands-on experience in LNP formulation and process development.
• Deep understanding of LNP composition, formation, purification, characterization, and relationships between process parameters and product attributes.
• Ability to lead complex technical programs, interpret data, troubleshoot, and establish development strategies.
• Experience leading and developing scientific teams and managing multiple programs and resources.
• Strong written, verbal, presentation, and client-facing communication skills.

Responsibilities

• Lead the LNP formulation, process development, and small-scale production function for partner and internal programs.
• Establish strategy and best practices for LNP formulation, process development, characterization, and production across multiple payloads.
• Provide senior technical leadership across programs, including development strategy, experimental planning, data review, risk mitigation, and recommendations.
• Serve as senior technical interface with clients and support proposals, scopes, and business development.
• Oversee non-GMP production of LNP formulations for in vitro, in vivo, and preclinical studies.
• Drive troubleshooting, process optimization, technology transfer, and continuous improvement of LNP production for various nucleic acids.
• Establish workflows and practices that improve quality, reproducibility, efficiency, and scalability.
• Lead, mentor, and develop the LNP team and manage priorities, resources, and growth.
• Collaborate cross-functionally to align development with program and company objectives.

Skills

LNP formulation

Process development

Leadership

Client-facing communication

Project management

Education

PhD in Pharmaceutical Sciences or related

MS with 14+ years or BS with 16+ years experience

Tools

LNP characterization

Job description

Mirai Bio is seeking an experienced Senior Director of Lipid Nanoparticle (LNP) Formulation & Process Development to lead LNP formulation, process development, and small-scale production for partner and internal programs in Cambridge, MA. The role blends scientific leadership with client engagement to advance multiple preclinical programs.

The candidate will drive strategy, build scalable operations, and mentor a growing team, ensuring high-quality formulations and successful technology transfer