Senior LNP Bioconjugation Scientist (On-Site)

MFS Investments; Boston (MA); Sur place; USD 75 000 - 112 000; Plein temps

Résumé du poste

Vertex is seeking a Senior Research Associate to join a collaborative Biologics conjugation and optimization team in Boston, MA. The role focuses on executing and improving laboratory workflows for lipid nanoparticle (LNP) conjugation and purification.

Independence, initiative, and curiosity are valued in this fast-paced lab environment. The successful candidate will perform conjugations, assist with bench-scale process development, analyze LNP quality attributes using DLS, HPLC, and RiboGreen

Qualifications

• Hands-on experience with conjugation strategies, preferably in ADC or antibody-oligonucleotide conjugation.
• Proficiency with LNP characterization techniques (DLS, RiboGreen, HPLC).
• Experience with TFF and sterile filtration is preferred.
• Ability to interpret routine data and adapt protocols for improvements.
• Ability to present results in oral and written forms.

Responsabilités

• Execute routine conjugations of ligands, scaffolds, and peptides to LNPs.
• Develop, optimize and troubleshoot tLNP conjugation and purification at bench and pilot scales.
• Analyze tLNP quality attributes using DLS, Ribogreen, HPLC and related methods.
• Plan experiments and perform some with limited supervision, documenting results.
• Maintain records in ELNs and prepare summaries for internal discussions.
• Contribute to platform development documentation and IP-related work.
• Maintain lab organization, supplies, and inventories for Bioconjugation team.

Connaissances

Conjugation techniques

LNP characterization

Data analysis

Experiment planning

Communication of results

Formation

Biological sciences degree

Masters degree or equivalent

Outils

HPLC

DLS

RiboGreen assay

Tangential flow filtration (TFF)

Description du poste

Vertex is seeking a Senior Research Associate to join a collaborative Biologics conjugation and optimization team in Boston, MA. The role focuses on executing and improving laboratory workflows for lipid nanoparticle (LNP) conjugation and purification.

Independence, initiative, and curiosity are valued in this fast-paced lab environment. The successful candidate will perform conjugations, assist with bench-scale process development, analyze LNP quality attributes using DLS, HPLC, and RiboGreen