Senior Scientist, LNP Formulation & In Vivo Studies

Kernal Biologics, Inc.; Boston (MA); On-site; USD 150,000 - 190,000; Full time

Benefits offered by this job

Competitive 401(k)

Healthcare coverage (PPO/HMO)

Free parking or subsidized commuter

Free Bluebike Membership

Gym Membership Support

Flexible Spending Account

Paid parental leave, family caregiver,

Paid life insurance coverage

On-site cafeteria

Competitive vacation and sick days

Job summary

Kernal Bio seeks an exceptional, highly motivated Senior Scientist to contribute to developing its targeting lipid nanoparticle platform. The successful candidate will work as part of the team responsible for developing and characterizing the manufacturing process of lipid nanoparticle systems, supporting the tech transfer to the CMC team and external partners, and analyzing/presenting results.

The role requires a PhD with industry experience, strong communication, and the ability to thrive in a

Qualifications

• PhD in Chemical Engineering, Biomedical Engineering, Bioengineering, Pharmaceutics, Chemistry, or related field.
• PhD with 2 years of industry experience in process development for LNPs or similar.
• Experience manufacturing LNPs using Microfluidics, T-mixer, or other inline mixers.
• Experience with tangential flow filtration (TFF) and sterile filtration.
• Proficiency with LNP/mRNA analytical techniques (HPLC, LC/MS, plate-based assays).
• Proficiency with in vivo LNP testing (IV administration, IVIS imaging).
• Proficiency with ELN and GraphPad Prism.
• Experience with DoE statistics.
• Nice to have: flow cytometry experience.
• Strong written and verbal communication; detail-oriented and a team player.

Responsibilities

• Develop and characterize novel LNP formulations and components using DLS, Ribogreen, HPLC, etc.
• Support flow cytometry-related experiments for LNP screening and optimization.
• Screen final formulation buffers and excipients to improve LNP stability.
• Execute in vivo experiments with LNP compositions.
• Develop new assays or investigations of specific LNP attributes.
• Develop, optimize, and troubleshoot LNP/mRNA manufacturing processes.
• Analyze, summarize, and present results to team members and management.
• Maintain stocks and supplies for LNP Formulation team.
• Participate in tech transfer activities to external partner programs.
• Maintain up-to-date records and prepare internal reports.
• Contribute to IP discussions related to Kernal’s proprietary technologies.

Skills

Communication skills

Attention to detail

Multi-tasking

Team collaboration

Independent work

Adaptability

Education

PhD in Chemical Engineering, Biomedical Engineering, Bioengineering, Pharmaceutics, Chemistry (related field)

Tools

Flow cytometry

HPLC

LC/MS

ELN

GraphPad Prism

Job description

Kernal Bio seeks an exceptional, highly motivated Senior Scientist to contribute to developing its targeting lipid nanoparticle platform. The successful candidate will work as part of the team responsible for developing and characterizing the manufacturing process of lipid nanoparticle systems, supporting the tech transfer to the CMC team and external partners, and analyzing/presenting results.

The role requires a PhD with industry experience, strong communication, and the ability to thrive in a