Senior Bioconjugation Scientist, LNP Platforms (Boston)

Vertex Pharmaceuticals LLC; Boston (MA); On-site; USD 75,000 - 112,000; Full time

Benefits offered by this job

Annual bonus

Equity awards

Paid time off

Job summary

Vertex Pharmaceuticals seeks a Senior Research Associate in Biologics/Bioconjugation for its Boston lab. You will execute and optimize LNP conjugation and purification workflows, analyze quality attributes with DLS, Ribogreen, and HPLC, and document results for internal discussions.

Independence and initiative are valued in a fast-paced research environment. The role emphasizes hands-on bench work, collaboration with cross-functional teams, and contribution to IP-related materials.

Qualifications

• Bachelors in biological sciences with 4+ years' relevant experience or Masters with 0-2 years' experience.
• Hands-on experience in conjugation strategies and lab workflows.
• Experience with LNP characterization techniques (DLS, Ribogreen, HPLC).
• Experience with tangential flow filtration and sterile filtration preferred.
• Ability to interpret routine data and present results clearly.
• Ability to adapt experimental designs for improvement.
• Strong written and oral communication skills for internal reporting.

Responsibilities

• Execute routine conjugations of ligands, scaffolds, and peptides to LNPs using established methods.
• Develop, optimize, and troubleshoot tLNP conjugation and purification at bench and pilot scales.
• Analyze tLNP critical quality attributes using DLS, Ribogreen, and HPLC.
• Plan experiments and perform work with limited supervision; follow up on results.
• Maintain detailed records in ELNs and prepare summaries for internal discussions.
• Contribute to platform development documents and IP-related discussions.
• Maintain laboratory organization, supplies, and reagent inventories.

Skills

Conjugation strategies

LNP characterization

Tangential flow filtration

Data interpretation

Scientific communication

Education

Bachelor's in Biological Sciences

Master's degree or equivalent

Tools

DLS

RiboGreen assay

HPLC

TFF (Tangential Flow Filtration)

Job description

Vertex Pharmaceuticals seeks a Senior Research Associate in Biologics/Bioconjugation for its Boston lab. You will execute and optimize LNP conjugation and purification workflows, analyze quality attributes with DLS, Ribogreen, and HPLC, and document results for internal discussions.

Independence and initiative are valued in a fast-paced research environment. The role emphasizes hands-on bench work, collaboration with cross-functional teams, and contribution to IP-related materials.