Senior Research Associate Biologics/Bioconjugation

Vertex Pharmaceuticals; Boston (MA); On-site; USD 75,000 - 112,000; Full time

Job summary

Vertex is seeking a Senior Research Associate to join a collaborative Biologics conjugation and optimization team in Boston, MA. The role focuses on executing and improving laboratory workflows for lipid nanoparticle (LNP) conjugation and purification.

Independence, initiative, and curiosity are valued in this fast-paced lab environment. The successful candidate will perform conjugations, assist with bench-scale process development, analyze LNP quality attributes using DLS, HPLC, and RiboGreen

Qualifications

• Hands-on experience with conjugation strategies, preferably in ADC or antibody-oligonucleotide conjugation.
• Proficiency with LNP characterization techniques (DLS, RiboGreen, HPLC).
• Experience with TFF and sterile filtration is preferred.
• Ability to interpret routine data and adapt protocols for improvements.
• Ability to present results in oral and written forms.

Responsibilities

• Execute routine conjugations of ligands, scaffolds, and peptides to LNPs.
• Develop, optimize and troubleshoot tLNP conjugation and purification at bench and pilot scales.
• Analyze tLNP quality attributes using DLS, Ribogreen, HPLC and related methods.
• Plan experiments and perform some with limited supervision, documenting results.
• Maintain records in ELNs and prepare summaries for internal discussions.
• Contribute to platform development documentation and IP-related work.
• Maintain lab organization, supplies, and inventories for Bioconjugation team.

Skills

Conjugation techniques

LNP characterization

Data analysis

Experiment planning

Communication of results

Education

Biological sciences degree

Masters degree or equivalent

Tools

HPLC

DLS

RiboGreen assay

Tangential flow filtration (TFF)

Job description

Job Description

Vertex is seeking a talented Senior Research Associate to join a collaborative research team focused on Biologics conjugation and optimization in Boston, MA. The group's mission is to deliver next generation biologics and genetic therapies impacting several therapeutic areas. We are looking for a candidate with a strong desire to support the development of targeted lipid nanoparticle (tLNP). In this lab-based role, ideal candidate will execute and improve laboratory workflows for lipid nanoparticle (LNP) conjugation and purification. The candidate should be independent, accustomed to taking initiative, and bring enthusiasm and intellectual curiosity to Vertex's fast-paced research environment.

Key Duties and Responsibilities:

• Execute routine conjugations of various ligands, scaffolds, and peptides to LNPs using established and emerging methods
• Assist with the development, optimization, and troubleshooting of tLNP conjugation and purification processes at bench and pilot scales
• Analyze tLNP critical quality attributes using techniques such as Dynamic Light Scattering (DLS), RiboGreen assays, HPLC, and related analytical methods
• Participates in planning of experiments and may perform some experiments with limited supervision demonstrating responsible follow-up
• Analyze experimental data, maintain detailed records in ELNs, and prepare summaries and presentations for internal team discussions
• Contribute to technical discussions and documentation related to conjugation platform development and intellectual property
• Maintain laboratory organization, supplies, and reagent inventories for the Bioconjugation team.

Knowledge and Skills:

• Hands on experience in various conjugation strategies. Preferred experience working in Antibody drug conjugates or Antibody oligonucleotide conjugation
• Proficiency in LNP characterization techniques such as DLS, Ribogreen assay, and HPLC methods is preferred
• Experience with tangential flow filtration (TFF) and sterile filtration preferred
• Exhibits reliable ability to interpret routine, uncomplicated data
• Applies technical knowledge to optimize some commonplace experimental procedures
• Displays emerging ability to modify experimental designs and protocols to enable experimental and/or methodological improvement
• Ability to present results in both oral and written reports

Education and Experience:

• Bachelors Degree in biological sciences and 4+ years of relevant employment experience or Masters Degree (or equivalent degree) and 0-2 years of experience

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

$74,800 - $112,200

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]