Senior Bioconjugation Scientist – LNP Therapies

Vertex Pharmaceuticals Incorporated; Boston (MA); On-site; USD 75,000 - 112,000; Full time

Benefits offered by this job

Annual bonus

Equity awards

Generous paid time off

401(k) matching

Job summary

Vertex seeks a Senior Research Associate in Boston, MA to join a collaborative team focused on Biologics conjugation and LNP work. The role emphasizes execution and improvement of laboratory workflows for LNP conjugation and purification in a lab-based environment.

The candidate should be independent, proactive, and eager to contribute to the development of targeted lipid nanoparticles, with the ability to analyze data, maintain ELN records, and present findings.

Qualifications

• Bachelor's degree in biological sciences and 4+ years of relevant employment experience or Master's degree (or equivalent degree) with 0-2 years of experience.
• Experience with conjugation strategies and LNP-related workflows is preferred.
• Familiarity with analytical techniques such as DLS, Ribogreen assays, and HPLC; experience with TFF is a plus.

Responsibilities

• Execute routine conjugations of ligands, scaffolds, and peptides to LNPs using established and emerging methods.
• Assist with development, optimization, and troubleshooting of tLNP conjugation and purification processes at bench and pilot scales.
• Analyze tLNP critical quality attributes using DLS, Ribogreen, HPLC and related methods.
• Plan experiments and perform some with limited supervision.
• Analyze data, maintain ELN records, and prepare summaries and presentations for internal discussions.
• Contribute to technical discussions and documentation related to conjugation platform development and IP.
• Maintain laboratory organization, supplies, and reagent inventories for the Bioconjugation team.

Skills

Conjugation strategies

LNP characterization

Tangential flow filtration

Data analysis

Experiment design optimization

Oral and written presentation

Education

Bachelor's in biological sciences

Master's degree or equivalent

Job description

Vertex seeks a Senior Research Associate in Boston, MA to join a collaborative team focused on Biologics conjugation and LNP work. The role emphasizes execution and improvement of laboratory workflows for LNP conjugation and purification in a lab-based environment.

The candidate should be independent, proactive, and eager to contribute to the development of targeted lipid nanoparticles, with the ability to analyze data, maintain ELN records, and present findings.