Senior Director, Translational Immunology & Biomarkers

Repertoire Immune Medicines; Watertown (MA); On-site; USD 260,000 - 315,000; Full time

Job summary

Repertoire Immune Medicines is seeking a seasoned, immunology-focused pharmacology leader to shape a portfolio of T cell-targeted therapies in oncology and autoimmune disease. You will define mechanism of action, establish PK/PD relationships, and translate modalities into clinically actionable programs.

You will drive development from discovery through IND-enabling studies, align discovery, platform, and development functions, and influence portfolio direction with a data-driven approach.

Qualifications

• PhD, MD, or MD/PhD in Immunology, or related discipline.
• Advanced clinical development and translational medicine expertise strongly preferred.
• Expertise in developing and executing translational medicine and biomarker strategies across clinical development programs.
• Proven ability to integrate scientific, biomarker, and clinical data to deepen the understanding of patient populations and drug mechanism of action in patients.
• Experience leading and influencing cross-functional teams across Research, Clinical Development, and Regulatory Affairs.
• Demonstrated success supporting programs from early clinical development through proof-of-concept and late-stage studies in oncology.

Responsibilities

• Lead development and execution of integrated translational medicine strategies across clinical development programs.
• Develop and continually refine biomarker and clinical pharmacology plans to support target engagement, proof-of-mechanism, proof-of-biology, dose optimization, and patient selection.
• Translate emerging biological, pharmacological, and clinical data into actionable development recommendations.
• Identify and prioritize translational milestones to inform key portfolio decisions and stage-gate transitions.
• Define biomarker strategies spanning exploratory, pharmacodynamic, predictive, prognostic, and diagnostic biomarkers.
• Partner with bioanalytical and laboratory teams to develop, validate, and implement clinical biomarker assays.
• Lead interpretation of biomarker, PK/PD, and clinical datasets to generate insights regarding mechanism of action, treatment response, and resistance pathways.
• Support implementation of innovative technologies and emerging translational approaches.
• Contribute to study design, protocol development, endpoint selection, statistical analysis planning, and clinical study execution.
• Build productive relationships with internal stakeholders, external partners, CROs, academic investigators, key opinion leaders, and laboratory vendors.
• Contribute translational components to regulatory submissions including INDs, briefing documents, and marketing applications.
• Support interactions with health authorities related to biomarkers, companion diagnostics, and translational strategy.
• Maintain awareness of emerging scientific advances and competitive developments within oncology, immunology, and related therapeutic areas.
• Foster a collaborative, patient-focused, and scientifically rigorous culture.
• Contribute to departmental strategy, capability building, and organizational development.

Skills

Translational medicine

Biomarker strategies

Cross-functional leadership

Immunology expertise

Data integration

Education

PhD/MD/MD-PhD in Immunology

Tools

Biomarker assays

Job description

Repertoire Immune Medicines is seeking a seasoned, immunology-focused pharmacology leader to shape a portfolio of T cell-targeted therapies in oncology and autoimmune disease. You will define mechanism of action, establish PK/PD relationships, and translate modalities into clinically actionable programs.

You will drive development from discovery through IND-enabling studies, align discovery, platform, and development functions, and influence portfolio direction with a data-driven approach.