Senior Director of Pharmacology – Translational Leader

Flagship Pioneering, Inc.; Somerville (MA); Sur place; USD 180 000 - 248 000; Plein temps

Avantages offerts par ce poste

Healthcare coverage

Annual incentive program

Retirement benefits

Broad range of other benefits

Résumé du poste

Cellarity seeks a highly strategic Sr. Director, Pharmacology to connect biology, pharmacology, DMPK, and translational science across inflammation and hematology programs.

You will partner with biology, chemistry, DMPK, toxicology, CROs, and leadership to drive programs from early discovery through candidate selection. Responsibilities include leading preclinical pharmacology strategy, PK/PD interpretation, exposure–response assessment, data integration, and oversight of outsourced studies.

Qualifications

• PhD in biology, pharmacology, or a related scientific discipline with 10–15+ years of experience in biotech or pharma.
• Strong foundation in preclinical pharmacology translating biology into in vivo efficacy and PK/PD insight.
• Experience connecting in vitro findings to in vivo outcomes, including target engagement and translational biomarker strategy.

Responsabilités

• Lead preclinical pharmacology strategy across multiple discovery programs, translating in vitro biology to in vivo outcomes.
• Drive PK/PD interpretation, exposure–response assessment, target coverage analysis, and translational biomarker strategy.
• Integrate data across biology, pharmacology, medicinal chemistry, and DMPK to build clear scientific narratives for candidate advancement.
• Oversee outsourced pharmacology studies and manage external CRO relationships on rigorous, objective-driven studies.
• Collaborate with internal teams to define critical experiments and determine additional studies needed for progression.
• Provide strategic input to cross-functional program discussions from discovery through candidate selection.
• Represent pharmacology at internal meetings, communicating findings, risks, and recommendations clearly.
• Contribute to broader translational approaches as the preclinical pipeline expands.

Connaissances

Strategic leadership

Data interpretation

Cross-functional collaboration

External CRO management

Formation

PhD in biology/pharmacology

Description du poste

Cellarity seeks a highly strategic Sr. Director, Pharmacology to connect biology, pharmacology, DMPK, and translational science across inflammation and hematology programs.

You will partner with biology, chemistry, DMPK, toxicology, CROs, and leadership to drive programs from early discovery through candidate selection. Responsibilities include leading preclinical pharmacology strategy, PK/PD interpretation, exposure–response assessment, data integration, and oversight of outsourced studies.