Sr. Director, New Target Validation & Translational Immunology

BioSpace; Indianapolis (IN); On-site; USD 153,000 - 264,000; Full time

Benefits offered by this job

Bonus

Comprehensive benefits

401(k) and pension

Vacation benefits

Job summary

Lilly Immunology is seeking a Director/Senior Director for New Target Validation within Discovery Immunology in Indianapolis. You will guide the biological strategy and translational readiness for projects, leading target identification through mechanistic validation and cross‑functional collaboration with internal teams, CROs, and academic partners.

The role requires a Ph.D. in Molecular Genetics and Immunology and 8–10 years of drug development experience, including work on autoimmune

Qualifications

• Required: Ph.D. in Molecular Genetics and Immunology.
• 8–10 years of drug development experience, with a strong focus including research on asthma, atopic dermatitis, and rheumatologic diseases.

Responsibilities

• Define and lead end-to-end strategy for new target validation, spanning genetic perturbation, pathway deconvolution, cellular pharmacology, and translational model design.
• Drive innovation through development of novel human systems for target validation (Organs‑on‑chip, ex vivo models, IPSC, HSC engineering).
• Integrate multimodal profiling (imaging, transcriptomics, cytokine and proteomics) to strengthen human disease relevance and predictive validity.
• Communicate workplans that drive scientific decision-making across multidisciplinary teams and ensure robust rationale and data-supported progression criteria.
• Train discovery biologists in molecular biology designs and building functional assays.
• Guide cross-functional project teams through influence across a matrixed organization.

Skills

Target validation strategy

Translational immunology

Leadership

Data interpretation

Education

PhD in Molecular Genetics and Immunology

Job description

Lilly Immunology is seeking a Director/Senior Director for New Target Validation within Discovery Immunology in Indianapolis. You will guide the biological strategy and translational readiness for projects, leading target identification through mechanistic validation and cross‑functional collaboration with internal teams, CROs, and academic partners.

The role requires a Ph.D. in Molecular Genetics and Immunology and 8–10 years of drug development experience, including work on autoimmune