Senior Biotransformation Scientist & DMPK Leader

Vividion Therapeutics, Inc.; San Diego (CA); On-site; USD 150,000 - 220,000; Full time

Benefits offered by this job

Bonus eligible

Long-term incentives

401k with match

Medical, dental, vision

Job summary

Vividion Therapeutics, Inc. seeks a highly motivated Biotransformation expert to drive drug discovery and development through comprehensive metabolite profiling, in vitro and in vivo MetID studies, and CRO oversight.

The role includes interpreting mass spectra, guiding chemistry teams, and contributing to regulatory documents for clinical development. The ideal candidate will have a PhD with 7+ years of industry experience (or MS/BS with 12+ years), expertise in DMPK and ADME, and hands-on

Qualifications

• PhD in Organic Chemistry, Drug Metabolism, Pharmacokinetics, Pharmaceutical Sciences, or related discipline with 7+ years of industry experience; MS/BS with 12+ years’ experience will also be considered.
• Expertise in drug metabolism, in vitro enzyme kinetics, ADME assays and LC/MS bioanalytical methodology.
• Experience in working with radioactivity (3H and 14C) will be a bonus.
• Experience in designing, executing and reviewing biotransformation studies.
• Understanding of regulatory guidance as it pertains to biotransformation including MIST.
• Experience in biotransformation document preparation for regulatory submissions is a plus.

Responsibilities

• Design and conduct non-labeled and radiolabeled in vitro and in vivo biotransformation studies supporting drug discovery and development.
• Execute in vitro soft-spot and tox species selection MetID studies and conduct in vivo MetID studies.
• Manage and provide oversight for biotransformation studies conducted at CRO’s.
• Interact with multidisciplinary project teams.
• Lead DMPK studies supporting preclinical and clinical development.
• Work collaboratively across functions to optimize drug candidates and understand species differences across metabolite profiles in support of toxicology studies.
• Author reports, prepare data summaries and communicate results to project teams and management.
• Author regulatory submission documentation including IND summaries and Investigator Brochure.
• Mentor and motivate the in-house DMPK team.

Skills

DMPK expertise

Biotransformation

LC-MS bioanalysis

Enzymology

MetID studies

IND submissions

CRO oversight

Mentoring

Education

PhD in Organic Chemistry

MS/BS 12+ years experience

Tools

Mass spectrometry

LC-MS methods

Radiolabeling (3H/14C)

Job description

Vividion Therapeutics, Inc. seeks a highly motivated Biotransformation expert to drive drug discovery and development through comprehensive metabolite profiling, in vitro and in vivo MetID studies, and CRO oversight.

The role includes interpreting mass spectra, guiding chemistry teams, and contributing to regulatory documents for clinical development. The ideal candidate will have a PhD with 7+ years of industry experience (or MS/BS with 12+ years), expertise in DMPK and ADME, and hands-on