Lead Metabolite Profiling Scientist - Biotransformation

Alnylam Pharmaceuticals, Inc.; United States; In loco; USD 180.000 - 240.000; Tempo pieno

Descrizione del lavoro

Alnylam Pharmaceuticals seeks a Principal Scientist, Biotransformation & Metabolite Profiling to provide scientific leadership in drug metabolism and biotransformation characterization across discovery and development programs.

You will develop and execute integrated metabolite profiling strategies using state-of-the-art LC-HRMS/MS approaches and collaborate with DMPK, bioanalytical, pharmacology, toxicology, and other project teams to translate data into actionable insights on drug disposition

Competenze

• PhD in analytical chemistry, medicinal chemistry, pharmaceutical sciences, biochemistry, or drug metabolism with 6+ years of industry experience.
• Hands-on experience in drug metabolism, metabolite profiling, and metabolite identification for small molecules, peptides, RNAi, or related modalities.
• Expertise in LC-MS/MS and high-resolution mass spectrometry with capability to interpret complex MS/MS data.
• Ability to elucidate metabolite structures and biotransformation pathways; strong PK and tissue distribution understanding.

Mansioni

• Lead metabolite profiling and structural identification across plasma, urine, bile, tissues, and in vitro matrices.
• Apply LC-HRMS/MS approaches for detection, profiling, elucidation, and relative quantitation of metabolites.
• Conduct advanced MS data processing with Compound Discoverer, BioPharma Finder, ProMass, Mass MetaSite, and related software.
• Design biotransformation strategies using hepatocytes, liver fractions, lysosomal systems, serum, and tissues.
• Collaborate with DMPK, bioanalytical sciences, pharmacology, toxicology, and other functions to translate data into disposition insights.
• Coach staff, set goals, and evaluate performance; support IND-enabling activities and CRO method transfers as needed.

Conoscenze

Metabolite profiling

LC-MS/MS

Data interpretation

Biotransformation

Team leadership

Strategic planning

Formazione

PhD in analytical chemistry or related field

Strumenti

Thermo Compound Discoverer

BioPharma Finder

ProMass

Mass MetaSite

LC-HRMS/MS workflows

Descrizione del lavoro

Alnylam Pharmaceuticals seeks a Principal Scientist, Biotransformation & Metabolite Profiling to provide scientific leadership in drug metabolism and biotransformation characterization across discovery and development programs.

You will develop and execute integrated metabolite profiling strategies using state-of-the-art LC-HRMS/MS approaches and collaborate with DMPK, bioanalytical, pharmacology, toxicology, and other project teams to translate data into actionable insights on drug disposition