Senior Director/Vice President, Head of DMPK

VidaVinci, Inc.; Watertown (MA); On-site; USD 260,000 - 380,000; Full time

Job summary

VidaVinci, Inc. in Watertown, MA is seeking an experienced DMPK leader to partner across chemistry, biology and computation, applying ADME/PK expertise to guide modality design and program progression from hit to IND-enabling studies.

The role requires strong collaboration, scientific judgment, and the ability to communicate findings to leadership and external partners, with responsibility for mentoring DMPK staff.

Qualifications

• Ph.D. with 10+ years in industry DMPK.
• Deep small-molecule DMPK expertise with translational insight.
• Experience enabling discovery programs from early stages through IND-enabling studies.
• Broad expertise across in vitro ADME, in vivo PK, metabolism and PK/PD modeling.
• Thrives in fast-paced, timeline-driven environments and communicates clearly.

Responsibilities

• Drive DMPK strategy across modality platforms and programs.
• Lead in vitro ADME, metabolism, transporters, and DDI assessments.
• Direct in vivo PK and translational PK/PD modeling and dose projections.
• Partner with medicinal chemistry to guide DMPK-driven design.
• Oversee bioanalytical strategy and CRO management.
• Communicate findings to leadership and contribute to IND documentation.
• Mentor DMPK staff and scientific partners.

Skills

DMPK leadership

ADME/PK expertise

Translational modeling

PK/PD modeling

Team mentorship

Education

Ph.D. in relevant field

Job description

VidaVinci, Inc. is a venture-backed, privately held biotech company on a mission to pioneer "a new modality to end all modalities." Our goal is to revolutionize drug discovery at scale, address the toughest challenges of existing modalities, and unlock high-impact therapies for patients.

Backed by top-tier investors, the company is co-founded by Drs. Gregory Verdine and Hal Barron, renowned industry leaders known for taking on the most daring scientific challenges. Built on a bold vision to redefine therapeutic innovation, we are pushing the boundaries of what’s possible in medicine. Join us to shape the future of drug discovery.

SUMMARY

We are seeking an experienced and scientifically rigorous DMPK leader to partner across chemistry, biology, and computational teams to enable our modality platform and the discovery portfolio. This individual will apply deep ADME/PK expertise, mechanistic disposition insights, and translational modeling to guide modality design, compound optimization, drug delivery, and program advancement. The role spans early hit identification through candidate selection and IND-enabling studies, and requires strong collaboration, scientific judgment, and clear communication. This is a full-time, on-site role in Watertown, MA.

RESPONSIBILITIES

• Drive DMPK strategy across the modality platform and the programs; embed ADME/PK principles into compound design and optimization.
• Develop DMPK approaches for nontraditional modalities.
• Lead in vitro ADME, mechanistic metabolism, transporter, and DDI assessments.
• Direct in vivo PK and translational PK/PD modeling, dose projections, and exposure-response understanding.
• Partner with medicinal chemistry to guide design through DMPK-driven insights.
• Oversee bioanalytical strategy and sample analysis.
• Collaborate broadly across discovery to support platform innovation.
• Manage CROs delivering ADME, PK, bioanalysis, and early DMPK/safety studies.
• Communicate findings to leadership, support BD/board materials, and contribute to IND documentation.
• Mentor and develop DMPK staff and scientific partners.

QUALIFICATIONS

• Ph.D. in a relevant discipline and with 10+ years of industry experience in DMPK required; experience in both large/mid-size pharma and small biotech strongly preferred.
• Deep small-molecule DMPK expertise required; experience extending ADME/PK approaches to novel or nontraditional modalities strongly preferred.
• Demonstrated success enabling discovery programs and emerging modalities from early stages through IND-enabling studies.
• Broad expertise across in vitro ADME, in vivo PK, metabolism, transporters, and PK/PD modeling, with strong mechanistic and translational insight.
• Proven ability to thrive in a fast-paced, timeline-driven environment, balancing scientific rigor with rapid decision-making.
• Effective communicator and matrix collaborator; publication/patent record a plus.