Senior DMPK Modeling Scientist

Vividion Therapeutics, Inc.; San Diego (CA); On-site; USD 130,000 - 175,000; Full time

Benefits offered by this job

Bonus potential

401k retirement plan with companymatch

Medical, dental, vision insurance

Job summary

Vividion Therapeutics, Inc. in San Diego is seeking a DMPK Modeling & Simulation Scientist to apply quantitative approaches that link preclinical data with clinical predictions.

You will build translational models to guide candidate selection, dose planning, and regimen decisions, working across multidisciplinary teams. The role may lead modeling activities and shape program strategy, using PK/PD, target engagement, and exposure-response approaches to drive forward translation to patients.

Qualifications

• Master’s or Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Chemical/Biomedical Engineering, or a related field.

Responsibilities

• Build and apply fit-for-purpose mechanistic and translational models (PBPK, PK/PD, TE) to support discovery and development programs.
• Integrate in vitro, in vivo, and clinical data using mechanistic and empirical modeling approaches to support first-in-human dose projections, clinical study design, regulatory submissions, and clinical pharmacology modeling and simulation.
• Characterize relationships among exposure, target engagement, pharmacodynamic response, efficacy, and safety to inform therapeutic index assessments, dose and regimen selection.
• Assess the impact of formulation, absorption, metabolism, transporters, and DDIs on pharmacokinetics.
• Evaluate variability and uncertainty in PBPK, PK/PD and target engagement predictions to support program and portfolio decisions.
• Present scientific findings to project teams, governance committees, external collaborators, and regulatory agencies.

Skills

PBPK modeling

PK/PD modeling

Differential equation-based modeling

Parameter estimation/optimization

Quantitative decision-making

Communication & cross-functionalCollab

Education

Master’s or Ph.D. in Pharmacokinetics/Pharmaceutical Sciences/Engineering

Tools

GastroPlus

Simcyp

PK-Sim

R

Python

Job description

Vividion Therapeutics, Inc. in San Diego is seeking a DMPK Modeling & Simulation Scientist to apply quantitative approaches that link preclinical data with clinical predictions.

You will build translational models to guide candidate selection, dose planning, and regimen decisions, working across multidisciplinary teams. The role may lead modeling activities and shape program strategy, using PK/PD, target engagement, and exposure-response approaches to drive forward translation to patients.