Scientist II - Analytical

Tech in Motion; San Diego (CA); On-site; USD 69,000 - 110,000; Full time

Job summary

Genentech is seeking a Scientist II - Analytical in San Diego, CA to analyze LNPs and components using HPLC and BLI. The role involves developing methods to characterize LNPs and maintaining detailed data records.

The ideal candidate has 5+ years in pharmaceutical sciences or related fields, with expertise in gradient-elution HPLC (RP/IPRP/AEX) and experience with BLI/SPR, LCMS, and data analysis tools. Collaboration and strong communication are essential.

Qualifications

• Bachelor’s or Master’s degree with 5+ years in pharmaceutical sciences, bioengineering, chemical engineering, chemistry, or related field.
• Experience developing methods in gradient-elution HPLC modalities such as RP, IPRP, or AEX is required.
• Experience with BLI or Surface Plasmon Resonance (SPR) is highly desirable
• Experience with LCMS is desirable
• Excellent attention to detail and ability to produce consistent results and effectively communicate them to the team
• Ability to be a team player, multitask and work on multiple projects in a collaborative environment.
• Proficiency in MS Excel; prior experience with Prism, JMP is desirable
• Excellent oral and written communication skills.

Responsibilities

• Work at the direction of Analytical scientists to analyze lipid nanoparticles (LNPs) encapsulating nucleic acids and LNP components using HPLC and Biolayer Interferometry (BLI)
• Develop methods to characterize LNPs and LNP components
• Establish relationships between physiochemical characteristics of experimental nanoparticle formulations and their efficacy and safety
• Maintain detailed records of analytical data
• Interface directly with other functional teams
• Share responsibility for basic lab management activities (supply ordering, instrument calibration, maintaining schedules)

Skills

Analytical skills

Attention to detail

Team collaboration

Communication skills

Multitasking

Education

Bachelors/Masters in pharmaceutical sciences or related

Tools

HPLC

Biolayer Interferometry (BLI)

Surface Plasmon Resonance (SPR)

LC-MS

Prism

JMP

MS Excel

Job description

Job Title: Scientist II - Analytical

Job Location: Onsite in San Diego, CA, 92111

Job Duration: 6 month contract, with extensions possible.

Position Summary

Genentech is searching for an outstanding Scientist II to join the Gene Medicines team in San Diego, CA. This position offers an exciting opportunity to work with new non-viral nucleic acid delivery tools for in vivo genome editing and gene therapy applications. This person will be engaged in the analysis of novel lipid nanoparticle-based pharmaceuticals.

Responsibilities

• Work at the direction of Analytical scientists to analyze lipid nanoparticles (LNPs) encapsulating nucleic acids and LNP components using HPLC and Biolayer Interferometry (BLI)


• Develop methods to characterize LNPs and LNP components


• Establish relationships between physiochemical characteristics of experimental nanoparticle formulations and their efficacy and safety


• Maintain detailed records of analytical data


• Interface directly with other functional teams


• Share responsibility for basic lab management activities (supply ordering, instrument calibration, maintaining schedules)

Requirements, Knowledge, Skills, and Abilities

• Masters or Bachelors degree with 5+ years experience in pharmaceutical sciences, bioengineering, chemical engineering, chemistry, or related scientific discipline (an equivalent combination of education and experience may be considered).


• Experience developing methods in gradient-elution HPLC modalities such as RP, IPRP, or AEX is required


• Experience with BLI or Surface Plasmon Resonance (SPR) is highly desirable


• Experience with LCMS is desirable


• Excellent attention to detail and ability to produce consistent results and effectively communicate them to the team


• Ability to be a team player, multitask and work on multiple projects at once, and excel in a collaborative work environment.


• Proficiency at MS Excel is required; prior experience with advanced analytical software (Prism, JMP) is desirable


• Excellent oral and written communication skills