Scientist II - Analytical

Spectraforce Technologies; San Diego (CA); On-site; USD 100,000 - 140,000; Full time

Job summary

Spectraforce Technologies, Inc. seeks an Analytical Scientist II to join the Gene Medicines team in San Diego, CA. You will analyze lipid nanoparticles using HPLC and BLI and develop methods to characterize LNPs and components for in vivo genome editing applications.

The role emphasizes data integrity, collaboration across functional teams, and participation in basic lab management, including instrument calibration and supply ordering, onsite in San Diego.

Qualifications

• Requires Master’s or Bachelor’s degree in pharmaceutical sciences, bioengineering, chemical engineering, chemistry, or related field; 5+ years of experience.
• Experience developing methods in gradient-elution HPLC modalities (RP, IPRP, or AEX) is required.
• Experience with BLI or SPR is highly desirable.
• LCMS experience is desirable.
• Strong attention to detail and ability to communicate results clearly.
• Able to multitask and collaborate across teams; proficient in Excel.

Responsibilities

• Analyze lipid nanoparticles (LNPs) encapsulating nucleic acids using HPLC and BLI.
• Develop methods to characterize LNPs and components.
• Correlate physiochemical properties with efficacy and safety.
• Maintain detailed records of analytical data.
• Interface with other functional teams and support lab management tasks.

Skills

Attention to detail

Communication

Team collaboration

Multitasking

Education

Bachelor’s or Master’s degree in pharmaceutical sciences or related field

Tools

HPLC

BLI

LCMS

PRISM

JMP

Excel

Job description

Position Title: Scientist II - Analytical
Work Location: San Diego, CA, 92111 (No relocations)
Assignment Duration: 6 month contract, with extensions possible
Work Arrangement: Onsite

Position Summary

The Organization is searching for an outstanding Scientist II to join the Gene Medicines team in San Diego, CA. This position offers an exciting opportunity to work with new non-viral nucleic acid delivery tools for in vivo genome editing and gene therapy applications. This person will be engaged in the analysis of novel lipid nanoparticle-based pharmaceuticals.

Key Responsibilities

• Work at the direction of Analytical scientists to analyze lipid nanoparticles (LNPs) encapsulating nucleic acids and LNP components using HPLC and Biolayer Interferometry (BLI)
• Develop methods to characterize LNPs and LNP components
• Establish relationships between physiochemical characteristics of experimental nanoparticle formulations and their efficacy and safety
• Maintain detailed records of analytical data
• Interface directly with other functional teams
• Share responsibility for basic lab management activities (supply ordering, instrument calibration, maintaining schedules)

Qualification & Experience

• Master's or Bachelor's degree with 5+ years experience in pharmaceutical sciences, bioengineering, chemical engineering, chemistry, or related scientific discipline (an equivalent combination of education and experience may be considered).
• Experience developing methods in gradient-elution HPLC modalities such as RP, IPRP, or AEX is required
• Experience with BLI or Surface Plasmon Resonance (SPR) is highly desirable
• Experience with LCMS is desirable
• Excellent attention to detail and ability to produce consistent results and effectively communicate them to the team
• Ability to be a team player, multitask and work on multiple projects at once, and excel in a collaborative work environment.
• Proficiency at MS Excel is required; prior experience with advanced analytical software (Prism, JMP) is desirable
• Excellent oral and written communication skills